| Diagnostic implications of urinary liver-type fatty acid-binding protein and 8-hydroxy-2'-deoxyguanosine in forensic autopsy cases. | |
| | |
MedLine Citation:
|
PMID: 23273867 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND/AIM: Liver-type fatty acid-binding protein (L-FABP) is a clinical biomarker of the progress of kidney disease. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is known as a biomarker of peroxidative DNA damage. We investigated both urinary L-FABP and 8-OHdG in forensic autopsy cases as biomarkers to elucidate the metabolic changes in survival periods after insults. METHODS: In 196 urinary samples from forensic autopsy cases, we measured L-FABP and 8-OHdG by enzyme-linked immunosorbent assay (ELISA) and creatinine by enzymatic assay. Urinary L-FABP/Cr and 8-OHdG/Cr were obtained. RESULTS: No significant correlation was observed between urinary L-FABP/Cr or 8-OHdG/Cr, and gender, age, or postmortem interval. Regarding urinary L-FABP/Cr or 8-OHdG/Cr, there were no significant differences among the causes of death. In the survival/agony period, urinary L-FABP/Cr under the cut-off value 31.3 might show that the survival/agony period was within 1h. Under the cut-off value of urinary 8-OHdG/Cr, 17.8, might indicate that it is within 24h. CONCLUSION: Urinary L-FABP/Cr may rise within a relatively short survival/agony period, and urinary 8-OHdG/Cr may increase when the damage continues longer. Measuring the urinary L-FABP/Cr and 8-OHdG/Cr might be useful in elucidating the survival/agony period. |
| | |
Authors:
|
Masayuki Kashiwagi; Tomoko Sugimura; Aya Matsusue; Kenji Hara; Brian Waters; Shin-Ichi Kubo |
Related Documents
:
|
9727427 - Arteriovenous malformations of the head and neck: natural history and management. 19307507 - Serum amyloid a as a prognostic marker in melanoma identified by proteomic profiling. 8420567 - Resection for esophageal carcinoma at a virginia hospital 1981-1989. 1495347 - Esthesioneuroblastoma: the ucla experience 1970-1990. 18804907 - Treatment with sunitinib enabled complete resection of massive lymphadenopathy not prev... 19878007 - Comparison of survival rates for geriatric horses versus nongeriatric horses following ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-25 |
Journal Detail:
|
Title: Legal medicine (Tokyo, Japan) Volume: - ISSN: 1873-4162 ISO Abbreviation: Leg Med (Tokyo) Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100889186 Medline TA: Leg Med (Tokyo) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, Japan. Electronic address: kasiwagi@fukuoka-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Insight into variable fetal heart rate decelerations from a mathematical model.
Next Document: Evaluation of the genotoxic and cytotoxic effects of glyphosate-based herbicides in the ten spotted ...