| Diagnostic impact of 18F-FDG PET-CT evaluating solid pancreatic lesions versus endosonography, endoscopic retrograde cholangio-pancreatography with intraductal ultrasonography and abdominal ultrasound. | |
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MedLine Citation:
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PMID: 18481063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This prospective single-centre phase II trial assessed the diagnostic impact of (18)F-FDG PET-CT in the evaluation of solid pancreatic lesions (phi >or= 10 mm) compared to endosonography (EUS), endoscopic retrograde cholangio-pancreatography (ERCP) with intraductal ultrasound (IDUS), abdominal ultrasound (US) and histopathological reference. METHODS: Forty-six patients (32 men/14 women, phi 61.7 years) with suspected pancreatic neoplasms underwent PET-CT with contrast-enhanced biphasic multi-detector CT of the upper abdomen followed by a diagnostic work-up with EUS, ERCP with IDUS and US within 3 weeks. PET-CT data sets were analysed by two expert readers in a consensus reading. Histology from surgery, biopsy/fine-needle aspiration and/or clinical follow-up >or=12 months served as standard of reference. RESULTS: Twenty-seven pancreatic malignancies were histopathologically proven; 19 patients had benign diseases: 36/46 lesions (78%) were detected in the head of the pancreas, 7/46 and 3/46 in the body and tail region, respectively. Sensitivity and specificity of PET-CT were 89% and 74%, respectively; positive predictive value (PPV) and negative predictive value (NPV) were 83% and 82%, respectively. Sensitivity (81-89%), specificity (74-88%), PPV (83-90%) and NPV (77-82%) achieved by EUS, ERCP and US were not significantly different. PET analysis revealed significantly higher maximum mean standardised uptake values (SUV(max) 6.5+/-4.6) in patients with pancreatic malignancy (benign lesions: SUV(max) 4.2+/-1.5; p<0.05). PET-CT revealed cervical lymphonodal metastasis from occult bronchogenic carcinoma and a tubular colon adenoma with intermediate dysplasia on polypectomy, respectively. CONCLUSIONS: (18)F-FDG PET-CT achieves a comparably high diagnostic impact evaluating small solid pancreatic lesions versus conventional reference imaging modalities. Additional clinical diagnoses are derived from concomitant whole-body PET-CT imaging. |
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Authors:
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Verena Schick; Christiane Franzius; Torsten Beyna; May Lin Oei; Jürgen Schnekenburger; Matthias Weckesser; Wolfram Domschke; Otmar Schober; Walter Heindel; Thorsten Pohle; Kai Uwe Juergens |
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Publication Detail:
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Type: Clinical Trial, Phase II; Comparative Study; Journal Article Date: 2008-05-15 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 35 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2009-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1775-85 Citation Subset: IM |
Affiliation:
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Department of Medicine B, Muenster University Hospital, Albert-Schweitzer-Strasse 33, 48149 Muenster, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cholangiopancreatography, Endoscopic Retrograde* Endoscopy, Digestive System* Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Pancreatic Neoplasms / diagnosis* Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Subtraction Technique Tomography, X-Ray Computed / methods* Ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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