Document Detail

Diagnostic imaging of patients in a memory clinic: comparison of MR imaging and 64-detector row CT.
MedLine Citation:
PMID:  19635835     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the assessment of global cortical atrophy (GCA), medial temporal lobe atrophy (MTA), and white matter changes (WMCs) in patients screened at a memory clinic with a 64-detector row computed tomography (CT) brain protocol, in comparison with the reference standard, magnetic resonance (MR) imaging. MATERIALS AND METHODS: The study protocol was approved by the local institutional review board. Written informed consent was obtained from all participants. Thirty patients (21 men, nine women; median age, 62 years) who presented to a memory clinic underwent 64-detector row CT and multisequence MR imaging of the brain on the same day. Three readers blinded to the clinical diagnosis assessed the resultant images. Images were presented in random order and scored for GCA, MTA, and WMC with published visual rating scales. Intermodality agreement between CT and MR imaging (intrareader agreement across both modalities), expressed by weighted kappa analysis, and interobserver agreement within each modality between readers (Kendall W test) were assessed. RESULTS: Overall, excellent intraobserver agreement between CT and MR imaging was observed for GCA (mean kappa, 0.83) and MTA (mean kappa, 0.88 and 0.86 on the left and right sides of the brain, respectively). There was substantial overall agreement concerning WMC (mean kappa, 0.79). For all three tested scales, interobserver variability was low and comparable for CT and MR imaging. CONCLUSION: Use of 64-detector row brain CT yields reliable information that is comparable with that obtained with MR imaging. Thus, multidetector row CT is a suitable diagnostic imaging tool in a memory clinic setting.
Mike P Wattjes; Wouter J P Henneman; Wiesje M van der Flier; Oscar de Vries; Frank Träber; Jeroen J G Geurts; Philip Scheltens; Hugo Vrenken; Frederik Barkhof
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-07-27
Journal Detail:
Title:  Radiology     Volume:  253     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-30     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-83     Citation Subset:  AIM; IM    
Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
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MeSH Terms
Aged, 80 and over
Brain Diseases / diagnosis*,  pathology
Cerebral Cortex / pathology*
Image Interpretation, Computer-Assisted
Incidental Findings
Magnetic Resonance Imaging / methods*
Middle Aged
Prospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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