Document Detail


Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses.
MedLine Citation:
PMID:  19338986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the frequency of abnormal results for evidence-based diagnostic tests differed among women with recurrent pregnancy loss (RPL) based on the number of prior losses (n = 2, 3, or > or =4) and to determine whether abnormal results for additional investigative diagnostic tests differed in prevalence among women with different numbers of pregnancy losses. DESIGN: Single-center, retrospective study. SETTING: Patients with RPL at a private practice. PATIENT(S): One thousand twenty women who had two or more consecutive spontaneous pregnancy losses with the same partner. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Frequencies of abnormal results for evidence-based diagnostic tests considered definite or probable causes of RPL (karyotyping for parental chromosomal abnormalities; pelvic sonohysterography, hysterosalpingogram, or hysteroscopy for uterine anomalies; immunological tests for lupus anticoagulant and anticardiolipin antibodies; thrombophilic tests for the factor V Leiden mutation; and blood tests for thyroid-stimulating hormone [TSH] and fasting blood glucose). We also measured the frequency of abnormal results for nine additional investigative tests in the same patients (antiphosphatidyl serine antibodies, microbial infection, midluteal P, PRL, functional protein C activity, functional protein S activity, antithrombin activity, fasting homocysteine and methylenetetrahydrofolate reductase polymorphisms, and factor II mutation). RESULT(S): The prevalence of abnormal results for evidence-based and investigative diagnostic tests did not differ among women with different numbers of pregnancy losses. CONCLUSION(S): Evaluation of all couples with two, three, or more consecutive miscarriages is recommended.
Authors:
Carolyn R Jaslow; Judi L Carney; William H Kutteh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-31
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-04-01     Revised Date:  2010-09-03    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1234-43     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Biology, Rhodes College, University of Tennessee, Memphis, Tennessee, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / diagnosis*,  genetics,  immunology,  pathology
Adult
Blood Glucose / metabolism
Cohort Studies
Diagnostic Tests, Routine* / methods
Female
Humans
Karyotyping
Male
Middle Aged
Pregnancy
Retrospective Studies
Risk Factors
Thyrotropin / blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 9002-71-5/Thyrotropin
Comments/Corrections
Comment In:
Fertil Steril. 2010 Sep;94(4):e61   [PMID:  20633877 ]

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