Document Detail

Diagnostic evaluation of patients with suspected haemophagocytic lymphohistiocytosis.
MedLine Citation:
PMID:  23206255     Owner:  NLM     Status:  Publisher    
Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by severely disturbed immune homeostasis. It can affect all age groups. Diagnostic evaluation of the patient with suspected HLH has to address three main questions: (i) does the patient have HLH? There is no simple diagnostic test, but a number of clinical and laboratory criteria define this clinical syndrome. (ii) Can a trigger be identified? A variety of infections, malignant or autoimmune diseases can contribute to the disturbed immune homeostasis with important consequences for treatment. (iii) Does the patient suffer from a genetic disease predisposing to HLH? Recent advances in the understanding of the genetic and pathophysiological basis of HLH have enabled a better and more rapid answer to this question, which is relevant for prognosis and the decision to perform haematopoietic stem cell transplantation. This review summarizes the current diagnostic approach to the patient with HLH.
Kai Lehmberg; Stephan Ehl
Related Documents :
24619895 - Successful use of fondaparinux in a patient with heparin-induced thrombocytopenia while...
24724785 - Deleterious effects of non-branded versions of imatinib used for the treatment of patie...
2004235 - Sperm retrieval by electro-ejaculation. preliminary experience in patients with seconda...
7930415 - Pulmonary function in spinal muscular atrophy.
22722725 - Vulnerable long-term psychiatric inpatients need screening for physical-health problems...
2183285 - Cholecystokinin sonography: lack of utility in diagnosis of acute acalculous cholecysti...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  British journal of haematology     Volume:  -     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Department of Paediatric Haematology and Oncology, University Medical Centre, Hamburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The influence of the arid Andean high plateau on the phylogeography and population genetics of guana...
Next Document:  Cullin-RING Ubiquitin Ligase Family in Plant Abiotic Stress Pathways.