Document Detail

Diagnostic efficacy of MnDPDP in MR imaging of the liver. A phase III multicentre study.
MedLine Citation:
PMID:  9245958     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. MATERIAL AND METHODS: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 mumol/kg b.w. was administered by slow i.v. infusion, and 20-60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. RESULTS: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. CONCLUSION: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions.
C Wang; H Ahlström; S Ekholm; H Fagertun; M Hellström; A Hemmingsson; S Holtås; B Isberg; E Jonnson; M Lönnemark-Magnusson; S McGill; N O Wallengren; L Westman
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Journal Article; Multicenter Study    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  38     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-28     Completed Date:  1997-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  643-9     Citation Subset:  IM    
Department of Diagnostic Radiology, Uppsala University Hospital, Sweden.
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MeSH Terms
Aged, 80 and over
Contrast Media* / administration & dosage,  adverse effects
Edetic Acid / administration & dosage,  adverse effects,  analogs & derivatives*,  diagnostic use
Liver / pathology*
Liver Neoplasms / diagnosis,  secondary
Magnetic Resonance Imaging / instrumentation,  methods*,  statistics & numerical data
Manganese / administration & dosage,  adverse effects,  diagnostic use*
Middle Aged
Pyridoxal Phosphate / administration & dosage,  adverse effects,  analogs & derivatives*,  diagnostic use
Reg. No./Substance:
0/Contrast Media; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid; 7439-96-5/Manganese
Comment In:
Acta Radiol. 1997 Jul;38(4 Pt 2):623-5   [PMID:  9245954 ]

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