| Diagnostic effectiveness of TSH screening and of T4 with secondary TSH screening for newborn congenital hypothyroidism. | |
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MedLine Citation:
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PMID: 9694583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used a receiver operating characteristic (ROC) plot to evaluate the diagnostic accuracy of primary thyrotropin (TSH) screening, and compared it to the primary thyroxine (T4) with secondary TSH screening (T4/TSH) on a certain percentage of the lowest T4 value for newborn congenital hypothyroidism (CH). There were 2198 normal and 117 abnormal CH cases evaluated using both the Wallac Delfia neonatal TSH and neonatal T4 kits. The ROC areas of the primary TSH screening and T4/TSH screening were 0.9841 and 0.9557, respectively. Nine cases (out of 117 cases) of CH would have been misclassified if T4/TSH screening were used. These nine cases, however, were identified using primary TSH screening. We conclude that using primary TSH screening is more effective for mass screening in reducing false-positive and false-negative cases than the combined T4/TSH screening method. |
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Authors:
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S T Wang; S Pizzolato; H P Demshar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 274 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-10-13 Completed Date: 1998-10-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 151-8 Citation Subset: IM |
Affiliation:
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Neonatal/Chemistry Lab, Ontario Ministry of Health, Etobicoke, Canada. wangst@gov.on.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Hypothyroidism* False Negative Reactions False Positive Reactions Humans Hypothyroidism / diagnosis* Infant, Newborn Neonatal Screening* Reagent Kits, Diagnostic Reproducibility of Results Thyrotropin / blood* Thyroxine / blood* |
| Chemical | |
Reg. No./Substance:
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0/Reagent Kits, Diagnostic; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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