Document Detail


Diagnostic and biological implications of mel-CAM expression in mesenchymal neoplasms.
MedLine Citation:
PMID:  9816205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mel-CAM (previously MUC18) is an integral membrane glycoprotein involved in heterophilic intercellular adhesions. Mel-CAM is expressed specifically in certain normal mesenchymal tissues, including smooth muscle, endothelium, and Schwann cells. As a member of the immunoglobulin supergene family of cell adhesion molecules (CAMs), Mel-CAM may play a pivotal role in the normal differentiation and functional activity of these tissues. To determine the distribution of Mel-CAM in mesenchymal neoplasms and to investigate its potential role as a factor in tumor progression, we evaluated a spectrum of mesenchymal neoplasms by immunohistochemistry using a Mel-CAM-specific polyclonal antibody on formalin-fixed tissues. Mel-CAM positivity was observed in 5 (100%) of 5 leiomyomas, 29 (91%) of 32 leiomyosarcomas, 5 (100%) of 5 hemangiomas, 5 (100%) of 5 angiosarcomas, 3 (100%) of 3 Kaposi's sarcomas, 8 (100%) of 8 schwannomas, 10 (100%) of 10 neurofibromas, 0 (0%) of 8 malignant peripheral nerve sheath tumors, 2 (15%) of 13 malignant fibrous histiocytomas, 0 (0%) of 8 fibrosarcomas, 0 (0%) of 7 synovial sarcomas, and 0 (0%) of 6 liposarcomas. These results show that Mel-CAM is expressed consistently in neoplasms of smooth muscle and vascular origin, and that immunostaining for Mel-CAM may serve as a useful adjunct in differentiating leiomyosarcomas, angiosarcomas, and Kaposi's sarcomas from other spindle cell neoplasms. Furthermore, the observation that Mel-CAM is expressed consistently in schwannomas and neurofibromas but not in malignant peripheral nerve sheath tumors implicates Mel-CAM as a potential modulator of malignant transformation in peripheral nerve tumors.
Authors:
I M Shih; T L Wang; W H Westra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  2     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1999-02-10     Completed Date:  1999-02-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  569-75     Citation Subset:  IM    
Affiliation:
Departments of Pathology and Human Genetics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-6971, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD*
Antigens, CD146
Cell Adhesion Molecules / analysis*
Humans
Immunohistochemistry
Liposarcoma / chemistry
Membrane Glycoproteins / analysis*
Neoplasms / chemistry*,  therapy
Neoplasms, Muscle Tissue / chemistry
Neural Cell Adhesion Molecules*
Peripheral Nervous System Neoplasms / chemistry
Vascular Neoplasms / chemistry
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD146; 0/Cell Adhesion Molecules; 0/MCAM protein, human; 0/Membrane Glycoproteins; 0/Neural Cell Adhesion Molecules

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