| Diagnostic approaches to acute transfusion reactions. | |
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MedLine Citation:
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PMID: 20140541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The erroneous transfusion of ABO-incompatible red cells may lead to life-threatening hemolysis and complement-induced shock, resulting in death in less than 10% of cases (acute hemolytic transfusion reaction, AHTR). Identification of the cause of an erroneous transfusion is accomplished in nearly all incidents merely by checking the identity of the patient, blood sample and blood bag. The erroneous transfusion is confirmed by serological and--in the case of a fatality- immunohistochemical methods. The differential diagnosis should rule out transfusion-related acute lung injury (TRALI), other immunologically triggered causes such as febrile nonhemolytic transfusion reaction (FNHTR) or allergic reactions, but also nonimmunological causes such as bacterial contamination of the blood components, transfusion-associated circulatory overload (TACO) and other rare events such as citrate overload or embolism (by air or debris). In the case of a fatality, evaluation of a patient's medical records, serological and microbiological analyses, autopsy and histology, taken together, clarify questions of causality. |
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Authors:
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A Leo; I Pedal |
Publication Detail:
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Type: Journal Article Date: 2010-02-06 |
Journal Detail:
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Title: Forensic science, medicine, and pathology Volume: 6 ISSN: 1556-2891 ISO Abbreviation: Forensic Sci Med Pathol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101236111 Medline TA: Forensic Sci Med Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 135-45 Citation Subset: IM |
Affiliation:
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Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg, University of Heidelberg, Heidelberg, Germany. Albrecht.Leo@iktz-hd.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System Acute Lung Injury / diagnosis, etiology Anaphylaxis / diagnosis, etiology Bacteremia / diagnosis, etiology Blood Group Incompatibility / complications, diagnosis Blood Transfusion / adverse effects* Embolism, Air / diagnosis, etiology Fever / diagnosis, etiology Forensic Medicine Heart Failure / diagnosis, etiology Humans Hypocalcemia / diagnosis, etiology Respiratory Distress Syndrome, Adult / diagnosis, etiology |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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