| Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT. | |
| | |
MedLine Citation:
|
PMID: 20717828 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To prospectively evaluate the diagnostic accuracy of whole-body T2-weighted (wbT2), whole-body diffusion-weighted imaging (wbDWI) and wbT2/wbDWI image fusion for malignant tumour detection compared with PET/CT. METHODS: Sixty-eight patients (44 men; 60 ± 14 years) underwent PET/CT for staging of malignancy and were consecutively examined by 1.5-Tesla MRI including wbT2 and wbDWI. Two radiologists independently assessed wbDWI, wbT2, wbT2 + wbDWI (side-by-side) and wbT2 + wbDWI + wbT2/wbDWI image fusion for the presence of malignancy. PET/CT served as a reference standard. RESULTS: PET/CT revealed 374 malignant lesions in 48/64 (75%) patients. Detection rates and positive predictive value (PPV) of wbT2 and wbDWI alone were 64% and 84%, and 57% and 93%, respectively. Detection rates and PPV of wbT2 and wbDWI for side-by-side analysis without and with fused images were 72% and 89%, and 74% and 91%, respectively. The detection rate was significantly higher with side-by-side analysis and fused image analysis compared with wbT2 and wbDWI alone (p = .0159; p < .0001). There was no significant difference between fused image interpretation and side-by-side analysis. CONCLUSIONS: WbDWI allows detection of malignant lesions with a similar detection rate to wbT2. Side-by-side analysis of wbT2 and wbDWI significantly improves the overall detection rate and fused image data provides no added value. |
| | |
Authors:
|
Michael A Fischer; Daniel Nanz; Thomas Hany; Caecilia S Reiner; Paul Stolzmann; Olivio F Donati; Stefan Breitenstein; Paul Schneider; Dominik Weishaupt; Gustav K von Schulthess; Hans Scheffel |
Related Documents
:
|
9255148 - Staging recurrent metastatic colorectal carcinoma with pet. 15100648 - Octreotide scintigraphy in the detection of recurrent paragangliomas. 8574048 - Imaging of ovarian cancer. 18568138 - 18f-fdg positron emission tomography ct (fdg pet-ct) in the management of pancreatic ca... 12456048 - Ct and mri rating of white matter changes. 19772478 - Quantitative magnetic resonance imaging assessment of matrix development in cell-seeded... |
Publication Detail:
|
Type: Journal Article Date: 2010-08-18 |
Journal Detail:
|
Title: European radiology Volume: 21 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 246-55 Citation Subset: IM |
Affiliation:
|
Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistr. 100, 8091, Zurich, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of non-cardiogenic acute pulmonary edema in a patient with POEMS syndrome-associated pulmonar...
Next Document: Differentiation of oncocytoma and renal cell carcinoma in small renal masses (<4 cm): the role of 4...