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Diagnostic accuracy of transvaginal sonography in the detection of uterine abnormalities in infertile women.
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PMID:  23329979     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Accurate diagnosis of uterine abnormalities has become a core part of the fertility work-up. A variety of modalities can be used for the diagnosis of uterine abnormalities.
OBJECTIVES: This study was designed to assess the diagnostic accuracy of transvaginal ultrasonography (TVS) in uterine pathologies of infertile patients using hysteroscopy as the gold standard.
PATIENTS AND METHODS: This was a cross-sectional study carried out in the Department of Reproductive Imaging at Royan Institute from October 2007 to October 2008. In this study, the medical documents of 719 infertile women who were investigated with transvaginal ultrasound (TVS) and then hysteroscopy were reviewed. All women underwent hysteroscopy in the same cycle time after TVS. Seventy-six out of 719 patients were excluded from the study and 643 patients were studied. TVS was performed in the follicular phase after cessation of bleeding. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for TVS. Hysteroscopy served as the gold standard.
RESULTS: The overall sensitivity, specificity, positive and negative predictive values for TVS in the diagnosis of uterine abnormality was 79%, 82%, 84% and 71%, respectively. The sensitivity and PPV of TVS in detection of polyp were 88.3% and 81.6%, respectively. These indices were 89.2% and 92.5%, respectively for fibroma, 67% and 98.3%, respectively for subseptated uterus and 90.9% and 100%, respectively for septated uterus. Adhesion and unicornuated uterus have the lowest sensitivity with a sensitivity of 35% and PPV of 57.1%.
CONCLUSION: TVS is a cost-effective and non-invasive method for diagnosis of intrauterine lesions such as polyps, submucosal fibroids and septum. It is a valuable adjunctive to hysteroscopy with high accuracy for identification and characterization of intrauterine abnormalities. This may lead to a more precise surgery plan and performance.
Maryam Niknejadi; Hadieh Haghighi; Firoozeh Ahmadi; Fatemeh Niknejad; Mohammad Chehrazi; Ahmad Vosough; Deena Moenian
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Publication Detail:
Type:  Journal Article     Date:  2012-09-17
Journal Detail:
Title:  Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society     Volume:  9     ISSN:  1735-1065     ISO Abbreviation:  Iran J Radiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-01-21     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101233229     Medline TA:  Iran J Radiol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  -    
Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Tehran, Iran.
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Journal Information
Journal ID (nlm-ta): Iran J Radiol
Journal ID (iso-abbrev): Iran J Radiol
Journal ID (doi): 10.5812/iranjradiol
Journal ID (publisher-id): Kowsar
ISSN: 1735-1065
ISSN: 2008-2711
Publisher: Kowsar
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Copyright © 2012, Tehran University of Medical Sciences and Iranian Society of Radiology
Accepted Day: 28 Month: 7 Year: 2012
Received Day: 23 Month: 2 Year: 2011
Revision Received Day: 30 Month: 6 Year: 2012
Electronic publication date: Day: 17 Month: 9 Year: 2012
Print publication date: Month: 9 Year: 2012
Volume: 9 Issue: 3
First Page: 139 Last Page: 144
PubMed Id: 23329979
ID: 3522369
DOI: 10.5812/iranjradiol.8063

Diagnostic Accuracy of Transvaginal Sonography in the Detection of Uterine Abnormalities in Infertile Women Alternate Title:Transvaginal Sonography in Uterine Abnormalities
Maryam Niknejadi1*
Hadieh Haghighi1
Firoozeh Ahmadi1
Fatemeh Niknejad1
Mohammad Chehrazi2
Ahmad Vosough1
Deena Moenian1
1Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Tehran, Iran
2Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Iranian Academic Center for Education, Culture & Research (ACECR), Tehran, Iran
*Corresponding author: Maryam Niknejadi, Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P.O.Box: 19395-4644, Tehran, Iran. Tel.: +98-2123562446, Fax: +98-2122409314, E-mail: mniknejadi@royaninstitute.orgmniknezhady1390@

1. Background

Diagnosis of congenital anomalies and acquired diseases of the uterus have long been obstacles to successful treatment of infertility. Uterine factors are responsible for 2-3% of infertility cases and intra-uterine lesions are much more common in infertile women (40-50%) (1). Structural pathologies in the uterine cavity such as congenital mullerian anomalies and intrauterine lesions can affect endometrial receptivity, resulting in implantation failure that manifests as recurrent pregnancy loss or infertility (2). Since the results of TVS and hysterosonography and hysterosalpingography are mostly in agreement with each other, this modality has recently become the only mandatory step in the initial investigation of uterine abnormalities before resorting to invasive procedures such as hysteroscopy (3, 4, 5). TVS is readily available and cost effective and non-invasive, therefore it is universally preferred as the initial diagnostic procedure for evaluating uterine structural pathologies. It is also well-known as a valuable adjunctive to hysteroscopy and laparoscopy for identification and characterization of intrauterine abnormalities. This may lead to a more precise surgery plan and biopsy performance (6). A similar study was previously published at Royan Institute when the diagnostic accuracy of transvaginal sonogarphy in infertile patients with endometrial polyp was evaluated (7). In that study, we had a conclusive look at endometrial polyps because of the high frequency of this abnormality between all intrauterine abnormalities (8) and its importance in infertility. The increased awareness of radiologists towards intra-uterine lesions can lead to a more accurate treatment.

2. Objectives

In the recent study we aim to evaluate the diagnostic efficacy of TVS in the detection of all uterine abnormalities.Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for TVS considering hysteroscopy as the gold standard.

3. Patients and Methods
3.1. Patient Selection

This study was performed at Royan Institute (Infertility Clinic & Reproductive Biomedicine Research) and approved by Royan Research Center Ethics Committee. The patients were 20 to 45-year-old healthy infertile women with a history of primary or secondary infertility of more than 1 year. Exclusion criteria were as follows: all patients with no accurate visualization of the endometrium due to sonographic evaluation in improper time, heterogenic or echogenic endometrium because of bleeding. The indications for hysteroscopy were respected failed IVF or failed IUI, observed focal endometrial pathology such as polyp or submucosal myoma, irregular endometrium and synechiae, mullerian anomalies observed in hysterosalpingography or TVS.

3.2. Sonographic Examination

TVS was performed in the follicular phase of the cycle (days 5-13) after cessation of bleeding and before diagnostic hysteroscopy using an Aloka α-10-color Doppler with a transvaginal 6 MHz probe. TVS and hysteroscopy were both performed in the same cycle. All sonographic examinations were done by an expert radiologist with 10 years of experience. The endometrial cavity was inspected in two perpendicular plane sagittal and transverse views. Irregularities, thickness, echo pattern and any distortion of the endometrium were noted. Uterine cavity abnormalities including polyp lesions, uterine fibroids, uterine congenital anomalies such as septum, adhesion and endometrial hyperplasia were investigated. A polyp is a round or oval localized echogenic lesion located in the endometrial cavity with intact endometrial-myometrial junction. Submucosal fibroma is a benign tumor that originates from the smooth muscle layer and the accompanying connective tissue of the uterus and is seen in sonography as a mixed or hypoechoic mass lesion that originates from the myometrium and interrupts the endometrial stripe. Other types of fibroma such as intramural and subserosal types were excluded from this study because diagnosis of these pathologies is done by laparoscopy and MRI. Septum is a form of congenital malformation that partitions the uterine cavity by a longitudinal short or long wall where the outside of the uterus has a normal typical concave shape. Other kinds of congenital anomalies such as unicornuated uterus, bicornuated uterus and didelphys are also evaluated. The documentation of congenital uterine anomalies was based on classification of the American Society for Reproductive Medicine. The best view for detection of any congenital anomaly is the transverse plane in two dimensional sonography and the coronal view in three dimensional sonography. Adhesion is a fibrous band which separates the endometrial cavity and causes an abnormal adhesion which is detected as an irregular endometrial line in sonography. Hyperplasia is a condition of excessive proliferation of the cells of the endometrium which presents as thickening of the endometrium detected on sonography.

3.3. Hysteroscopic Examination

Hysteroscopy was performed under general anesthesia using a Storz 4mm hysteroscope (Karl. Storz – GmbH and Co. Tuttlingen, Germany) by an expert gynecologist. Distention of the cavity was obtained using a glycine serum. The number, size and location of the endometrial polyps or myoma were investigated. All women with significant clinical abnormalities which were detected by hysteroscopy underwent operative hysteroscopy at once and the specimens obtained were sent for histological examination. The percentage of uterine pathologies diagnosed by hysteroscopy is illustrated in a pie chart in Figure 1. In this study, the gynecologist was not blind to the ultrasonography results.

3.4. Statistical Methods

The sensitivity, specificity, positive and negative predictive values of TVS and also the positive and negative likelihood ratio with confidence intervals were calculated with hysteroscopic findings used as the gold standard. Data were analyzed using Stata version 11 (Stata Corp., College Station, TX).

4. Results

A total of 643patients were evaluated with both sonography and hysteroscopy. In the sight of hysteroscopy, 253 cases were detected as normal (39%) and 394 cases were pathologic, which included 197 polypoid lesions (50%), 33 long uterine septa (8%), 91 short uterine septa (23%), 28 uterine fibroids (7%), 21 adhesions (5%) and 16 endometrial hyperplasia (4%). Sonography and hysteroscopy results were in agreement in 350 pathologic cases (88.1%). However, sonography was not able to diagnose some pathologies such as 23 polypoid lesions, 30 subseptated, three long uterine septa, 14 adhesions, seven endometrial hyperplasia and three unicornuate uteruses (Table 1).

4.1. Polyp Lesions

Of the total 643 accomplished hysteroscopies, polypoid lesions were observed in 197 patients (30%). In this respect, hysteroscopy was in agreement with sonography in 174 patients (88.3%), while sonography failed to detect 23 of the 197 cases (11.7%). Of the total 197 diagnosed polyps, 132 cases were sent to the pathology lab and 110 cases (83%) were confirmed; moreover, 21 proliferative endometriums and one endometrial hyperplasia were diagnosed by pathology. The residual 65 cases were not sent to the pathology lab or pathologic results were not referred to the clinic by patients. Out of the 39 cases in which sonography had detected polyps within the endometrium and hysteroscopy had not, 14 patients underwent Dillation and Curettage operation and in three patients (21%), polypoid lesions were observed, so we suggest D & C diagnosis operation in similar cases (Table 2). In the false negative group where sonography had failed to diagnose polyps, 19 patients had a pathology report as follows: endometrial polyp (9/19) and proliferative endometrium (10/19). Thus, in 10 cases a misdiagnosis had occurred by hysteroscopy.

4.2. Uterine Fibroids

Of the total 28 uterine fibroids observed in patients by hysteroscopy, sonography results were in agreement with the hysteroscopy results in 25 cases (89.3 %,) but there was disagreement between the two techniques in three cases (10.7 %) (Table 2). In this study, we only considered the submucosal fibroma that may be further investigated by hysteroscopy and other types of fibroma such as intramural and subserosal fibroma were ignored. Diagnosis of these types of fibroma should be done by MRI and laparoscopy.

4.3. Adhesion

Twenty-one cases of adhesion were observed by hysteroscopy, while sonography was not able to recognize only seven correct cases (33 %), but 14 cases were failed (Table 2). Among these failed cases, 85% (12/14) contained mild adhesions and in two severe adhesions sonography was able to diagnose correctly (Table 2).

4.4. Endometrial Hyperplasia

Hysteroscopy diagnosed 16 cases with endometrial hyperplasia, out of which in nine cases (56.2%) the result of sonography and hysteroscopy were in agreement, but disagreement between the results of these two techniques existed in seven cases. In the other two cases, the diagnosis of endometrial hyperplasia via sonography was not approved by hysteroscopy. In these nine cases of hyperplasia, which were confirmed with both sonography and hysteroscopy, the specimens were sent to the pathology laboratory and only in three cases hyperplasia was approved (Table 2).

4.5. Mullerian Anomalies

Of the total seven unicornuate uteri observed by hysteroscopy, in four cases, the results of sonography were similar to hysteroscopy (57.1%). Two unicornuate uteri were reported because the hysteroscope was entered into one cavity without any communication to the other cavity. In one case of didelphys uterus, both methods were in agreement. Hysteroscopy diagnosed 91 cases with short uterine septum and sonography was in agreement with the hysteroscopy result in 61 cases (67%), while the sonography results did not agree with that of hysteroscopy in 30 other cases (Table 2). Of the total 33 long uterine septa observed by hysteroscopy, in 30 cases, the results of sonography were similar with hysteroscopy (90.9%) and in three other cases, sonography failed to diagnose the anomalies due to a thin endometrium or fibromatose echo pattern of myometer that distorted the endometrium (Table 2).

5. Discussion

Various forms of female infertility were associated with congenital uterine anomalies and acquired uterine disease (3, 9). In general, TVS as a noninvasive and valuable diagnostic modality plays an important role in the evaluation of uterus and endometrial abnormalities (3, 10). The objective of this article was to assess the diagnostic value of TVS performed prior to routine hysteroscopy to confirm that TVS could reduce the number of diagnostic hysteroscopies commonly carried out in women with normal uterine cavities. Loverro et al. (9) and Soares et al. (11) have reported that TVS had a sensitivity and specificity of as high as (75-85%) and (90-100%), respectively for the detection of endometrial polyps. Using hysteroscopy as a gold standard, TVS showed excellent specificity (91.2%), good sensitivity (88.2%), an 81.4% PPV and a 94.6% NPV in uterine polyp detection in our setting. Likewise, the PPV of TVS for the detection of polyps in our setting was higher than that reported by Soares et al. (11). While, Fedele and colleagues reported that TVS had a misdiagnosis rate of 4.2% and was therefore less effective in distinguishing polyps than hysteroscopy (12). In cases of endometrial fibroids, TVS had a sensitivity of 89.2% and a specificity of 99.6%. These findings correlate with the result of Loverro et al. (9) in which TVS had a 90.9% sensitivity and a 100% specificity for the detection of endometrial fibroids. For the diagnosis of endometrial septum, TVS had a sensitivity of 67% and specificity of 99.8% in patients with a subseptated uterus, while the diagnostic accuracy of TVS is more significant in those patients with a long septum, which showed a sensitivity of 90.9% and specificity of 100% for endometrial long septum. In our study, TVS had 57.1% sensitivity and 100% positive predictive value for unicornuate uterus (Figure 2). Furthermore, Soares et al.(11) reported that TVS had a positive predictive value of 100% for uterine malformations detected in hysteroscopy of infertile patients. In this study, TVS failed to distinguish adhesions in 14 out of 21 patients (67%). While Fedele et al. (12) and Shalev et al. (3) reported a high accuracy of TVS in diagnosing uterine adhesions. It is recommended that in case of endometrial adhesion detected by sonography, the final diagnosis needs to be confirmed by salin infusion sonography (sonohysterography) which separates the two layers of the endometrium or by diagnostic hysteroscopy. In cases of endometrial hyperplasia, TVS had a sensitivity of 56.2% and a specificity of 99.6%. In this study, all patients were not referred for D & C and only nine cases had a pathologic report. Hyperplasia was approved in three out of nine cases and in six out of nine cases, focal hyperplasia was proved and proliferative endometrium was reported in the pathology test. Sonographic diagnosis of these three cases were correct; thus, endometrial hyperplasia cannot be diagnosed with hysteroscopy alone and the diagnosis of endometrial hyperplasia via hysteroscopy should be approved by a biopsy specimen (13). Overall, as a test for the detection of intra-uterine abnormalities, TVS had 79% sensitivity and 82% specificity, 84% positive predictive value and 71% negative predictive value in comparison with hysteroscopy. This study showed similar results to Narayan and Goswamy’s study which suggested TVS had a positive predictive value as high as 85-95% for specific uterine abnormalities detected by hysteroscopy in an infertile population (14). In this study, only histological diagnosis of resected endometrial tissues by hysteroscopy was available and obviously all patients with fibroma or mullerian duct anomalies had no histological results. In spite the fact that the most accurate diagnosis is based on pathological confirmation, the goal of this study was determining the agreement between the results of TVS and hysteroscopy which is determined by direct optic visualization which was the gold standard in the same study (15). Sonography is a safe, available and inexpensive method with multiple capacities such as 3D, 4D, Doppler studies and saline infusion (sonohysterography) which can properly diagnose uterine pathologies before hysteroscopy. Previous studies have mostly shown that sonohysterography is less invasive than hysteroscopy and in some circumstances may obviate diagnostic hysteroscopy (16-18). It may provide a specific diagnosis and enable the surgeon to proceed to operative hysteroscopy. This method is cost-effective, less complicated and less time consuming. It may be a proper alternative for diagnostic hysteroscopy saving more time and may help the surgeon perform the procedure more accurately.We conclude that TVS as a routine procedure before hysteroscopy enables the detection of the details of most localized endometrial lesion.


afn571Implication for health policy/practice/research/medical education: TVS is well known as the initial, available and noninvasive diagnostic procedure in detecting all uterine abnormalities and it is a valuable adjunctive to hysteroscopy and laparoscopy. The increased awareness of the radiologist towards intra-uterine lesions may lead to a more precise surgery plan and biopsy performance.

afn572Please cite this paper as: Niknejadi M, Haghighi H, Ahmadi F, Niknejad F, Chehrazi M, Vosough A, et al. Diagnostic Accuracy of Transvaginal Sonography in the Detection of Uterine Abnormalities in Infertile Women. Iran J Radiol. 2012;9(3):139-44. DOI: 10.5812/iranjradiol.8063

afn573Authors’ contribution: All authors contributed extensively to the work presented in this paper.

afn574Financial disclosure: None declared.

afn575Funding/support: None declared.

We appreciate the cooperation of our colleagues in the Department of Reproductive Imaging in Royan Institute.

1. Ait Benkaddour Y,Gervaise A,Fernandez H. [Which is the method of choice for evaluating uterine cavity in infertility workup?].J Gynecol Obstet Biol Reprod (Paris)Year: 20103986061310.1016/j.jgyn.2010.08.00420870363
2. Ahmadi F,Zafarani F,Haghighi H,Niknejadi M,Vosugh A. Application of 3D Ultrasonography in detection of uterine abnormalitiesIJFSYear: 2011441447
3. Shalev J,Meizner I,Bar-Hava I,Dicker D,Mashiach R,Ben-Rafael Z. Predictive value of transvaginal sonography performed before routine diagnostic hysteroscopy for evaluation of infertilityFertil SterilYear: 2000732412710.1016/S0015-0282(99)00533-610685552
4. Salim S,Won H,Nesbitt-Hawes E,Campbell N,Abbott J. Diagnosis and management of endometrial polyps: a critical review of the literatureJ Minim Invasive GynecolYear: 20111855698110.1016/j.jmig.2011.05.01821783430
5. La Sala GB,Blasi I,Gallinelli A,Debbi C,Lopopolo G,Vinci V,et al. Diagnostic accuracy of sonohysterography and transvaginal sonography as compared with hysteroscopy and endometrial biopsy: a prospective studyMinerva GinecolYear: 2011635421721926951
6. Vercellini P,Cortesi I,Oldani S,Moschetta M,De Giorgi O,Crosignani PG. The role of transvaginal ultrasonography and outpatient diagnostic hysteroscopy in the evaluation of patients with menorrhagiaHum ReprodYear: 199712817687110.1093/humrep/12.8.17689308809
7. Niknejadi M,Ahmadi F,Zafarani F,Khalili G,Ghaderi F,Rashidi Z. Diagnostic accuracy of transvaginalsonogarphy infertile patients with endometrial polypIJFSYear: 20103415760
8. Torre A,Pouly JL,Wainer B. [Anatomic evaluation of the female of the infertile couple].J Gynecol Obstet Biol Reprod (Paris)Year: 2010398Suppl 2S344410.1016/S0368-2315(10)70029-621185484
9. Loverro G,Nappi L,Vicino M,Carriero C,Vimercati A,Selvaggi L. Uterine cavity assessment in infertile women: comparison of transvaginal sonography and hysteroscopyEur J Obstet Gynecol Reprod BiolYear: 20011001677110.1016/S0301-2115(01)00434-111728660
10. Granberg S,Wikland M,Karlsson B,Norstrom A,Friberg LG. Endometrial thickness as measured by endovaginal ultrasonography for identifying endometrial abnormalityAm J Obstet GynecolYear: 19911641pt 147521986624
11. Soares SR,Barbosa dos Reis MM,Camargos AF. Diagnostic accuracy of sonohysterography, transvaginal sonography, and hysterosalpingography in patients with uterine cavity diseasesFertil SterilYear: 20007324061110.1016/S0015-0282(99)00532-410685551
12. Fedele L,Bianchi S,Dorta M,Vignali M. Intrauterine adhesions: detection with transvaginal USRadiologyYear: 1996199375798638001
13. Marchetti M,Litta P,Lanza P,Lauri F,Pozzan C. The role of hysteroscopy in early diagnosis of endometrial cancerEur J Gynaecol OncolYear: 2002232151312013114
14. Narayan R,Goswamy RK. Transvaginal sonography of the uterine cavity with hysteroscopic correlation in the investigation of in-fertilityUltrasound Obstet GynecolYear: 1993321293310.1046/j.1469-0705.1993.03020129.x12797307
15. Bingol B,Gunenc Z,Gedikbasi A,Guner H,Tasdemir S,Tiras B. Comparison of diagnostic accuracy of saline infusion sonohysterography, transvaginal sonography and hysteroscopyJ ObstetGynaecolYear: 201131154810.3109/01443615.2010.532246
16. Gronlund L,Hertz J,Helm P,Colov NP. Transvaginal sonohysterography and hysteroscopy in the evaluation of female infertility,habitual abortion or metrorrhagia. A comparative studyActa Obstet Gynecol ScandYear: 1999785415810.1034/j.1600-0412.1999.780513.x10326887
17. Cepni I,Ocal P,Erkan S,Saricali FS,Akbas H,Demirkiran F,et al. Comparison of transvaginalsonography, saline infusion sonography and hysteroscopy in the evaluation of uterine cavity pathologiesAust N Z J ObstetGynecolYear: 2005451305
18. Syrop CH,Sahakian V. Transvaginal sonographic detection of endometrialpolyps with fluid contrast augmentationObstet GynecolYear: 1992796104131579303


[Figure ID: fig212]
Figure 1  Percentage of uterine pathologies diagnosed by hysteroscopy

[Figure ID: fig213]
Figure 2  Sensitivity and PPV of TVS in different uterine pathologies during a one-year-study of infertile women

[TableWrap ID: tbl207] Table 1  Total Abnormal Findings by TVS and Hysteroscopy in 643 Patients
TVS a Hysteroscopy
Normal Findings 293 253
Polyps 213 197
Fibroma 25 28
Subseptated Uterus 61 91
Septated Uterus 30 33
Adhesion 7 21
Endometrial Hyperplasia 9 16
Unicornuate Uterus 4 7
Didelphys 1 1
Total Abnormal Findings 350 394
Total 643 647

fn141aAbbreviation: TVS, transvaginal ultrasonography

[TableWrap ID: tbl209] Table 2  Various Diagnostic Indices of TVS Compared with Hysteroscopy in Diagnosing Abnormal Uterine Findings
diagnostic Indices sensitivity (% 95 cI) specificity (% 95 cI) PPV a (% 95 cI) NPV a (% 95 cI) Positive likelihood ratio (% 95 cI) Negative likelihood ratio (% 95 cI)
Uterine Abnormalities
Polyps 88.3 ( 82.8-92.3) 91.2 (88.1-93.6) 81.6 (75.6-86.5 ) 94.6 ( 91.9-96.5) 10.1 (7.4-13.6) 0.12 (0.08-0.18)
Fibroma 89.2 ( 70.6-97.2) 99.6 (98.7-99.9) 92.5 ( 74.2-98.7) 99.5 ( 98.4-99.8) 274 (68.4-1101.8) 0.10 ( 0.03-0.31 )
Subseptated Uterus 67.0 (56.3-76.3) 99.8 (98.8-99.9) 98.3 ( 90.1-99.9) 94.6 ( 92.6-96.4) 370 (51.9-2636) 0.33 (0.24-0.44)
Septated Uterus 90.9 (74.5-97.6) 100 (99.0-100) 100 ( 85.8-100) 99.5 ( 98.1-99.8) infinity 0.09 (0.03-0.26)
Adhesion 33.3 (15.5-56.9) 99.8 (98.9-99.9) 87.5 ( 46.6-99.3) 97.9 (96.2-98.7 ) 207 (26.7-1610) 0.66 (0.49-0.90)
Endometrial Hyperplasia 56.2 (30.5-79.2) 99.6 (98.7-99.9) 81.8 ( 47.7-96.7) 98.8 ( 97.6-99.5) 176 (41.3-751.4) 0.43 (0.25-0.76)
Total 79 82 84 71

fn142aAbbreviation: NPV, negative predictive value; PPV, positive predictive value

Article Categories:
  • Urogenital Imaging & Contrast Media

Keywords: Ultrasonography, Diagnosis, Uterus.

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