| Diagnostic accuracy of thallium-201 myocardial perfusion imaging. | |
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MedLine Citation:
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PMID: 1884475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial thallium-201 (Tl-201) imaging performed in conjunction with exercise stress has enhanced the accuracy of detecting coronary artery disease among patients with chest pain. Sensitivity and specificity of qualitative visual Tl-201 scintigraphy for detection of coronary artery disease average 84% and 87%, respectively. Quantitative analysis of planar Tl-201 scintigrams has yielded sensitivity and specificity in the 90% range. Single photon emission computed tomographic imaging is associated with even higher sensitivity but with specificity in the 82-85% range. Perfusion defects representing ischemia can now be distinguished from scar by demonstration of delayed Tl-201 redistribution or enhanced uptake after reinjection of a second dose of Tl-201. Stenoses of the left circumflex coronary artery are less easily detected than lesions of the right and left anterior descending coronary arteries. False-positive Tl-201 perfusion defects may occur as a result of attenuation artifacts, most often caused by overlying breast tissue or by a high left hemidiaphragm. Patient motion during acquisition of single photon emission computed tomographic images results in artifactual defects on reconstruction. Abnormal Tl-201 uptake has been noted in patients with 1) left bundle branch block and normal coronary arteries, 2) hypertrophic cardiomyopathy, and 3) progressive systemic sclerosis. |
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Authors:
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G A Beller |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 84 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1991-10-04 Completed Date: 1991-10-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: I1-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bundle-Branch Block / radionuclide imaging Cardiomyopathy, Hypertrophic / radionuclide imaging Coronary Disease / radionuclide imaging* Diagnosis, Differential Dogs Heart / radionuclide imaging* Heart Diseases / radionuclide imaging* Humans Prognosis Scleroderma, Systemic / radionuclide imaging Thallium Radioisotopes / diagnostic use* Tomography, Emission-Computed, Single-Photon* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL-26205-09/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Thallium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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