| Diagnostic accuracy, reproducibility and robustness of fibrosis blood tests in chronic hepatitis C: a meta-analysis with individual data. | |
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MedLine Citation:
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PMID: 18655779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the diagnostic accuracy of liver fibrosis tests and its influencing factors in a meta-analysis with individual data. DESIGN AND METHODS: Four independent centers provided four blood tests and Metavir staging from 825 patients with chronic hepatitis C. RESULTS: FibroMeter AUROC (0.840) for significant fibrosis was superior to those of Fibrotest (0.803, p=0.049), APRI (0.789, p=0.001) and Hepascore (0.781, p<0.001). The misclassification rate was lower for FibroMeter (23%) than for Fibrotest and Hepascore (both 28%, p<0.001). The variation in the diagnostic cut-offs of tests among centers, reflecting the overall reproducibility, was: FibroMeter: 4.2%, APRI: 24.0%, Fibrotest: 24.2%, Hepascore: 35.0%. Accordingly, the proportion of patients diagnosed with significant fibrosis changed: FibroMeter: 0.8%, Hepascore: 2.4% (p=0.02 vs FibroMeter), Fibrotest: 5.8% (p<10(-3)), APRI: 18.2% (p<10(-3)). CONCLUSIONS: This study on clinical applicability shows significant differences in diagnostic accuracy, inter-center reproducibility, and robustness of biomarkers to changes in population characteristics between blood tests. |
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Authors:
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Vincent Leroy; Philippe Halfon; Yannick Bacq; Jérôme Boursier; Marie Christine Rousselet; Marc Bourlière; Anne de Muret; Nathalie Sturm; Gilles Hunault; Guillaume Penaranda; Marie-Claude Bréchot; Candice Trocme; Paul Calès |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2008-07-11 |
Journal Detail:
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Title: Clinical biochemistry Volume: 41 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1368-76 Citation Subset: IM |
Affiliation:
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Clinique d'Hépato-Gastroentérologie, Pôle Digestif-DUNE, CHU, Grenoble, France. VLeroy@chu-grenoble.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fibrosis Hematologic Tests / standards* Hepatitis C, Chronic / blood, diagnosis*, pathology* Humans Male ROC Curve Reproducibility of Results Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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