Document Detail

Diagnostic accuracy of radionuclide techniques in patients with equivocal electrocardiographic exercise testing.
MedLine Citation:
PMID:  2282928     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to evaluate the yield of radionuclide studies for the diagnosis of coronary artery disease (coronary artery narrowing greater than 50%) in a prospective series of 73 patients with thoracic pain and equivocal electrocardiographic stress testing. In the study population, the prevalence of coronary artery disease was 51%. The sensitivity, specificity, diagnostic accuracy and the post-test probability difference curves according to the Bayes' theorem were calculated for 201-thallium exercise testing and radionuclide exercise equilibrium ventriculography. For the latter study the following criteria were considered: (1) increase in left ventricular ejection fraction less than 5%; (2) the criterion proposed by Rozanski; (3) decrease in regional ejection fraction; and (4) abnormalities in phase and amplitude analysis (Fourier). 201-thallium exercise testing was the most sensitive (97%) and accurate (86%) study. Radionuclide ventriculography sensitivity was always lower for any criterion, although its best result was for evaluation of regional ejection fraction (85%). The most specific study was Fourier analysis (97%), although its sensitivity was low (42%). The application of Bayes' theorem to these results shows that the highest post-test probability difference values were achieved with 201-thallium exercise testing for prevalences higher than 40% and with Fourier analysis for lower prevalences.
J Candell-Riera; J Castell-Conesa; D Ortega-Alcalde; F M Domènech-Torné; J Soler-Soler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  11     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-03-19     Completed Date:  1991-03-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  980-9     Citation Subset:  IM    
Servicio de Cardiologia, Hospital General Vall d'Hebron, Barcelona, Spain.
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MeSH Terms
Coronary Disease / diagnosis,  radionuclide imaging*
Exercise Test*
Gated Blood-Pool Imaging*
Middle Aged
Prospective Studies
Sensitivity and Specificity
Thallium Radioisotopes / diagnostic use*
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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