Document Detail


Diagnostic accuracy of flow-mediated dilatation and intima-media thickness for the presence of significant coronary artery disease.
MedLine Citation:
PMID:  20409981     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Our purpose was to determine and compare the diagnostic accuracy of flow-mediated dilatation (FMD) and intima-media thickness (IMT). Included were 543 patients. FMD was performed in 543 patients, IMT in 233, and coronary arteriography (CAG) in 442. Analyzing ROC (receiver operating characteristic) curves, FMD </=5.64% showed 89% sensitivity, 62% specificity, 65% positive predictive value (PPV), and 88% negative predictive value (NPV) for the presence of angiographically significant coronary artery disease (CAD). IMT >/=0.788 mm had 71% sensitivity, 62% specificity, PPV 60%, and NPV 73% for the presence of advanced coronary atherosclerosis. FMD >8% or IMT <0.614 mm distinguished a group of patients with a low probability of advanced CAD (95% sensitivity for both and 91% and 81% NPV for FMD and IMT, respectively), whereas FMD </=0% or IMT >/=1.09 mm indicated a high probability for significant coronary stenosis (specificity 95% and NPV 71 and 67%, respectively). FMD and IMT have a clinically applicable diagnostic accuracy for the presence of angiographically significant CAD with a better performance for FMD. FMD and IMT values help us define zones with high and low probability for the presence of advanced coronary atherosclerosis.
Authors:
Iana Simova; Tsvetana Katova; Stefan Denchev
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  3     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2010-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  388-94     Citation Subset:  -    
Affiliation:
Department of Noninvasive Functional and Imaging Diagnostics, National Cardiology Hospital, Sofia, Bulgaria.
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