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Diagnostic accuracy of exhaled nitric oxide in exercise-induced bronchospasm: Systematic review.
MedLine Citation:
PMID:  22560771     Owner:  NLM     Status:  Publisher    
INTRODUCTION: The gold-standard method for the diagnosis of exercise-induced bronchospasm (EIB) is an exercise test combined with spirometry. However, this test is expensive, time consuming and requires specialized equipment and trained personnel. Exhaled nitric oxide (eNO) is a fast, easy, noninvasive method for the diagnosis of EIB. The aim of the present study was to assess the accuracy of the measurement of eNO for the diagnosis of EIB through a systematic review of the literature. METHODS: A search was carried out in the PubMed, Lilacs, SciELO and SCOPUS databases by two independent researchers. RESULTS: Fifty-six papers were found. Following the application of the eligibility criteria to the title, abstract and text, six papers remained for analysis. There was a significant heterogeneity in sex (X(2)=56.44, p=0.000) and clinical spectrum (X(2)=504.00, p=0.000) between studies. In children between 3.8 and 7.8 years old a cutoff point >28ppb EIB can be ruled in and in children between 5 and 16 years old at a cutoff point <20EIB can be ruled out. For adults a cutoff point <7EIB can be ruled out and it can be ruled in with a cutoff point >12. Four papers reported negative predictive values above 88%. CONCLUSION: The measurement of eNO seems to be effective for ruling in and ruling out EIB in some specific groups. Therefore, the meansurement of eNO levels could be an important tool to safely avoid the need for an exercise test when the result is negative, reducing the individual and economic impact of this disease.
L A S Feitosa; A Dornelas de Andrade; C M A Reinaux; M C A Britto
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-3
Journal Detail:
Title:  Revista portuguesa de pneumologia     Volume:  -     ISSN:  0873-2159     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9813736     Medline TA:  Rev Port Pneumol     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Sociedade Portuguesa de Pneumologia. Published by Elsevier España. All rights reserved.
Universidade Federal de Pernambuco, Recife, Brazil.
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