Document Detail


Diagnostic accuracy of exercise thallium-201 scintigraphy in men with asymptomatic essential hypertension.
MedLine Citation:
PMID:  1637519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coronary artery disease is responsible for much of the morbidity and mortality in patients with essential hypertension, and these complications have proven to be relatively resistant to antihypertensive therapy. However, the diagnosis of coronary disease in the hypertensive population has been considered problematic. In the present study, 30 asymptomatic patients with mild to moderate hypertension with positive exercise electrocardiograms (ECG) or stress thallium-201 scintigrams underwent coronary angiography to determine the accuracy of these tests for coronary artery disease. The exercise ECG was positive in 25 subjects, of whom 15 had significant coronary lesions and 10 did not. Thallium-201 scintigraphy proved more accurate: 17 of 18 patients with reversible abnormalities had significant obstructive coronary disease anatomically corresponding to the defect, one patient with a fixed defect had normal coronary arteries and was found to have an idiopathic cardiomyopathy, and 9 of 11 without defects had no significant lesions. The results were similar in populations with and without echocardiographic criteria for left ventricular hypertrophy. These findings indicate that despite previous suggestions to the contrary, thallium-201 scintigraphy can accurately diagnose coronary artery disease in most patients with asymptomatic essential hypertension, and that most asymptomatic hypertensive patients with physiologic evidence of myocardial ischemia have associated coronary artery disease.
Authors:
W L Chin; B O'Kelly; J F Tubau; J Szlachcic; D Brown; J A Wisneski; S Ammon; B M Massie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  5     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-01     Completed Date:  1992-09-01     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  465-72     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of California, San Francisco.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Coronary Angiography
Echocardiography
Electrocardiography
Evaluation Studies as Topic
Exercise Test / standards*
Humans
Hypertension / radiography,  radionuclide imaging*,  ultrasonography
Male
Middle Aged
Thallium Radioisotopes / diagnostic use*
Grant Support
ID/Acronym/Agency:
HL-07192/HL/NHLBI NIH HHS; HL-25847/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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