Document Detail

Diagnostic accuracy of 99Tcm-HIDA with cholecystokinin and gallbladder ejection fraction in acalculous gallbladder disease.
MedLine Citation:
PMID:  11403177     Owner:  NLM     Status:  MEDLINE    
The diagnostic accuracy and clinical impact of 99Tcm hepatic iminodiacetic acid (HIDA) imaging with cholecystokinin (CCK) was investigated in a prospective study of 359 patients over an 11 year period. All patients presented with right upper quadrant biliary type pain and had a normal ultrasound investigation prior to imaging. CCK was administered as a 3 min infusion at peak gallbladder uptake of HIDA. A gallbladder ejection fraction (GBEF) was used to quantify the gallbladder response to CCK. Two hundred and forty-four of 359 (68%) patients had an abnormal GBEF (< or = 35%). One hundred and thirty-four of 141 (95%) patients who underwent cholecystectomy had abnormal surgical/histological findings and/or relief of symptoms on long-term (mean 5.7 years) follow-up. Clinical follow-up, mean of 5.9 years, of the patients with GBEF > 35% showed 73/79 (92%) of them with little evidence of gallbladder disease. For a total 261 patients with mean clinical follow-up of 5.7 years the sensitivity of GBEF measurement is 95%, specificity is 92% and overall accuracy is 94%. It is concluded that 99Tcm-HIDA imaging, with a 3 min infusion of CCK, is a highly accurate technique and valuable in the diagnostic management of patients with suspected acalculous gallbladder disease.
G W Middleton; J H Williams
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  22     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  657-61     Citation Subset:  IM    
Department of Medical Physics and Clinical Engineering, University Hospital of Wales, Cardiff, UK.
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MeSH Terms
Bile Ducts / radionuclide imaging
Cholecystokinin / metabolism*
Follow-Up Studies
Gallbladder / metabolism*,  pathology,  radionuclide imaging*
Gallbladder Diseases / metabolism*,  pathology,  radionuclide imaging*
Prospective Studies
Radiopharmaceuticals / diagnostic use*
Technetium Tc 99m Lidofenin / diagnostic use*
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Technetium Tc 99m Lidofenin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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