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Diagnostic accuracy of [(18) F]fluoro-L-DOPA PET scan for persistent congenital hyperinsulinism in Japan.
MedLine Citation:
PMID:  21521340     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:  We aimed to elucidate the accuracy and limitations of (18) F-fluoro-L-dihydroxyphenylalanine ([(18) F]DOPA) positron emission tomography (PET) for Japanese patients with congenital hyperinsulinism. Although [(18) F]DOPA PET is reported to be useful for precisely localising the focal form of congenital hyperinsulinism, previous reports are mostly from European and North American centres. Patients:  Seventeen Japanese infants with congenital hyperinsulinism. Measurements:  [(18) F]DOPA PET studies were performed, and the results were assessed by simple inspection or by a quantitative measurement termed the 'Pancreas Percentage', which expresses the uptake of the head, body, or tail of the pancreas as a percentage of the total maximum standardised uptake value of the whole pancreas. The results were compared with those of other studies, including genetic analysis and histology. Results:  By simple inspection, when a single focal uptake was obtained, the localisation and histology were correct in all cases that underwent pancreatectomy. However, the overall results were consistent with the molecular diagnosis and histology in only 7/17 and 6/12 patients, respectively. The inaccuracy of PET studies by inspection was due to elevated background uptake that mimicked a diffuse or multifocal appearance. The accuracy improved substantially using the Pancreas Percentage; it was consistent with the molecular diagnosis and histology in 10/17 and 9/12 patients, respectively. Conclusions:  In contrast to the results of previous reports, [(18) F]DOPA PET appears to be less efficient for diagnosing Japanese patients with congenital hyperinsulinism. However, the diagnostic accuracy is substantially improved when this technique is combined with the Pancreas Percentage.
Authors:
Michiya Masue; Hironori Nishibori; Seisuke Fukuyama; Akihiko Yoshizawa; Shinya Okamoto; Ryuichiro Doi; Shinji Uemoto; Tetsuji Tokumi; Takeshi Kasai; Tohru Yorifuji
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-11
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Pediatrics, Kizawa Memorial Hospital Department of Radiology, Kizawa Memorial Hospital Department of Roentgenology, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital Department of Laboratory Medicine, Shinshu University Hospital Department of Pediatric Surgery, Otsu Red Cross Hospital Department of Surgery, Otsu Red Cross Hospital Department of Pediatric Surgery, Kyoto University Hospital Department of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital.
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