| Diagnostic values of metabolic syndrome definitions for detection of insulin resistance: Tehran Lipid and Glucose Study (TLGS). | |
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MedLine Citation:
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PMID: 23020535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study examines the characteristics and agreement between different definitions of metabolic syndrome (MetS) and insulin resistance (IR). METHODS: A total of 347 non-diabetic individuals who were ≥ 20 years of age were selected from the Tehran Lipid and Glucose Study (TLGS). Subjects were categorized as having MetS by the Adult Treatment Panel III (ATP III) and the Joint Interim Statement (JIS). IR was estimated by using the homeostasis model assessment (HOMA-IR). RESULTS: According to ATP III and JIS criteria 38.9% and 38.2% of subjects had MetS respectively. The sensitivity of ATP III was 52.3% and specificity was 65%; for JIS the sensitivity was 52.3%, with a specificity of 66.5%. Kappa between ATP III or JIS and HOMA-IR was 0.14 and 0.16, respectively. Based on receiver operating characteristic (ROC) analysis, the use of waist circumference (WC) and fasting plasma glucose (FPG) for the diagnosis of IR in women showed a diagnostic accuracy equal to or instead of counting MetS components using modified ATP III or JIS. WC optimal cut points for prediction of IR were 93.5 cm for men and 92.5 cm for women. CONCLUSIONS: ATP III and JIS definitions have low sensitivities and specificities for detecting IR. There is poor agreement between these criteria and IR. |
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Authors:
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Farhad Hosseinpanah; Shiva Borzooei; Maryam Barzin; Marjan Farshadi; Farzaneh Sarvghadi; Fereidoun Azizi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of Iranian medicine Volume: 15 ISSN: 1735-3947 ISO Abbreviation: Arch Iran Med Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: 2013-02-04 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 100889644 Medline TA: Arch Iran Med Country: Iran |
Other Details:
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Languages: eng Pagination: 606-10 Citation Subset: IM |
Affiliation:
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Obesity Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Science, Tehran, Iran. fhospanah@endocrine.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blood Glucose / analysis Body Mass Index Female Humans Insulin Resistance* Iran / epidemiology Male Metabolic Syndrome X / diagnosis*, epidemiology Middle Aged Predictive Value of Tests Prospective Studies ROC Curve Sensitivity and Specificity Waist Circumference |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
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