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Diagnostic Value of Simultaneous Measurement of Procalcitonin, Interleukin-6 and hs-CRP in Prediction of Early-Onset Neonatal Sepsis.
MedLine Citation:
PMID:  22708043     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations.We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive- C reactive protein(hs-CRP) in prediction of early neonatal sepsis.A follow-up study was performed on 95 neonates who were below 12 hours (h) of age and had clinical signs of sepsis or maternal risk factors for sepsis. Neonates were assigned to 4 groups including "proven early-onset sepsis", "clinical early-onset sepsis", "negative infectious status", and "uncertain infectious status". Blood samples were obtained within the first 12 h of birth repeated between 24 hours and 36 hours of age for determination of serum levels of PCT, IL-6, hs-CRP, and white blood cell (WBC) count.On admission, neonates with sepsis had a higher WBC count, IL-6, PCT, and hs-CRP levels compared with those neonates without sepsis. This remained significant even after 12-24 hours of admission. Also, patients with clinical evidences of sepsis had a higher serum level of PCT and IL-6 within 12-24 hours after admission compared to the patients with uncertain sepsis.The combination of PCT and IL-6 yielded had a sensitivity of 88% and PCT and CRP (using the cutoff value of 8 mg/L) a sensitivity of 82%.The areas under the ROC curve for the two periods were 0.801, and 0.819 respectively.In final The combination of IL-6, hs-CRP, and PCT seems to be predictive in diagnosis of early onset neonatal sepsis.
Authors:
Alireza Abdollahi; Saeed Shoar; Fatemeh Nayyeri; Mamak Shariat
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Publication Detail:
Type:  Journal Article     Date:  2012-05-06
Journal Detail:
Title:  Mediterranean journal of hematology and infectious diseases     Volume:  4     ISSN:  2035-3006     ISO Abbreviation:  Mediterr J Hematol Infect Dis     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-10-02     Revised Date:  2013-03-05    
Medline Journal Info:
Nlm Unique ID:  101530512     Medline TA:  Mediterr J Hematol Infect Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e2012028     Citation Subset:  -    
Affiliation:
Division of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences Tehran, Iran.
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