| Diagnostic Value of N-Terminal Pro-Brain Natriuretic Peptide in Pleural Effusions of Cardiac Origin. | |
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MedLine Citation:
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PMID: 21474229 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: The diagnosis of cardiogenic pleural effusion (PE) is often difficult to make. The objective of our study was to evaluate the diagnostic usefulness of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in PE patients with heart failure, in pleural fluid (PF) and blood (B), and to compare the cholesterol in pleural fluid (CHOL PF) and in serum (CHOL S) with the Light criteria. PATIENTS AND METHODS: All the biomarkers were evaluated in 398 PF (26.9% transudates). The area under the curve (AUC) quantified the overall diagnostic precision. The diagnostic precision of the different parameters was also assessed using the ROC curves. RESULTS: The AUC of the ROC for pleural fluid NT-proBNP was 0.894, with no significant differences with CHOL LP (0.914) or with the Light criteria (0.896). The sensitivity, specificity, the positive probability ratio (PPR) and negative probability ratio (NPR) were 85.1% (94.1% for CHOL LP), 79.9% (90.2% for the Light criteria), 4.24 (7.27 for the Light criteria) and 0.19 (0.07 for CHOL LP), respectively. The combination of NT-proBNP in PF ≥ 276pg/ml and CHOL LP ≤ 57mg/dL managed to classify the highest number PE correctly (sensitivity 97.8%, specificity 85.4%). Conclusions. The diagnostic yield of NT-proBNP in cardiogenic PE is not superior to the CHOL LP or the Light criteria, although it could be diagnostic in transudates of another origin. |
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Authors:
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Luis Valdés; Esther San José; Antonio Pose; Francisco J González-Barcala; José M Alvarez-Dobaño; Lucía Ferreiro; Christian Anchorena; Marco F Pereyra; José R González-Juanatey; Steven A Sahn |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
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Title: Archivos de bronconeumologia Volume: - ISSN: 1579-2129 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354720 Medline TA: Arch Bronconeumol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 SEPAR. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Neumología, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, España. |
Vernacular Title:
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Valor diagnóstico de los niveles del N-terminal pro-péptido natriurético cerebral en los derrames pleurales de origen cardiaco. |
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