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Diagnostic Utility of Urine Protein to Creatinine Ratio for Identifying Proteinuria in Pregnancy.
MedLine Citation:
PMID:  23020712     Owner:  NLM     Status:  Publisher    
Abstract Objective: To evaluate urine protein to creatinine ratio (UPC) alone and with uric acid and clinical factors to predict or exclude significant proteinuria in preeclampsia evaluations. Study Design: Retrospective cohort study patients undergoing evaluation for preeclampsia. Greater than 300 mg of protein in a 24-hour collection was the gold standard defining proteinuria against which UPC performance was measured. Bivariable, multivariable and ROC analyses were performed. Sensitivity, specificity, predictive values and likelihood ratios were calculated for multiple cut points of UPC alone and with uric acid. Results: In a cohort of 356 patients, the area under the curve for UPC in the diagnosis of proteinuria was 0.81. No single cut-point of UPC was diagnostic of preeclampsia. UPC values ≤0.08 or ≥1.19 have useful negative or positive predictive values of 86% and 96%. Uric acid and clinical factors did not improve the detection of significant proteinuria. Conclusion: Extreme values of UPC ratio ≤0.08 or ≥1.19 have favorable predictive values, which could enable the rapid diagnosis of preeclampsia without a 24 hour urine collection.
Molly J Stout; Christina M Scifres; David M Stamilio
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
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