Document Detail

Diagnostic Power of the Mid-regional Pro-Atrial Natriuretic Peptide for Heart Failure Patients with Dyspnea: A Meta-analysis.
MedLine Citation:
PMID:  22981931     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To evaluate the diagnostic performance of the mid-regional portion of the pro-atrial natriuretic peptide (MR-proANP) for heart failure (HF) in dyspnea patients. Design and Methods We performed a systematic review of English-language studies published during the past three decades. The performance characteristics (diagnostic sensitivity, specificity, and other measures of accuracy) were pooled and examined by random-effects models. RESULTS: Five studies met the inclusion criteria, which included 1,153 patients with HF and 1,904 non-HF patients. The summary estimates for MR-proANP in HF diagnosis had a diagnostic sensitivity of 0.90 (95% confidence interval (CI), 0.88-0.92), a specificity of 0.68 (95% CI, 0.66-0.70), and a diagnostic odds ratio (DOR) of 22.89 (95% CI, 12.54-41.77). The area under the curve (AUC) and Q value for the summary receiver operating characteristic (sROC) curves were 0.88 and 0.81, respectively. CONCLUSION: MR-proANP showed a high diagnostic accuracy for HF in dyspnea patients.
Zhide Hu; Zhijun Han; Yuanlan Huang; Yi Sun; Bo Li; Anmei Deng
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-12
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region. Ji'nan 250031, China; Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University. Shanghai 200433, China.
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