Document Detail

Diagnostic markers of Sjögren's syndrome.
MedLine Citation:
PMID:  20502032     Owner:  NLM     Status:  In-Process    
Establishing a diagnosis of Sjögren's syndrome (SS) has been difficult without sensitive laboratory markers, and in light of the non-specificity of the symptoms of dry eyes and mouth. Rather than complaints about dry eyes or dry mouth, objective symptoms and extraglandular manifestations should raise suspicion of SS. This evaluation requires the detection of antibodies against Ro (SSA) and La (SSB) or a pathologic salivary gland biopsy. Since an invasive biopsy is not always performed, further diagnostic markers are required. Recently antibodies against alpha-fodrin have been shown to be present in the majority of untreated patients, and can be used in the screening process of SS as an additional marker.
Torsten Witte
Publication Detail:
Type:  Journal Article     Date:  2010-05-18
Journal Detail:
Title:  Developments in ophthalmology     Volume:  45     ISSN:  0250-3751     ISO Abbreviation:  Dev Ophthalmol     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010321     Medline TA:  Dev Ophthalmol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany.
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