| The diagnostic and clinical significance of café-au-lait macules. | |
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MedLine Citation:
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PMID: 20888463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Café-au-lait, also referred to as café-au-lait spots or café-au-lait macules, present as well-circumscribed, evenly pigmented macules and patches that range in size from 1 to 2 mm to greater than 20 cm in greatest diameter. Café-au-lait are common in children. Although most café-au-lait present as 1 or 2 spots in an otherwise healthy child, the presence of multiple café-au-lait, large segmental café-au-lait, associated facial dysmorphism, other cutaneous anomalies, or unusual findings on physical examination should suggest the possibility of an associated syndrome. While neurofibromatosis type 1 is the most common syndrome seen in children with multiple café-au-lait, other syndromes associated with one or more café-au-lait include McCune-Albright syndrome, Legius syndrome, Noonan syndrome and other neuro-cardio-facialcutaneous syndromes, ring chromosome syndromes, and constitutional mismatch repair deficiency syndrome. |
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Authors:
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Kara N Shah |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric clinics of North America Volume: 57 ISSN: 1557-8240 ISO Abbreviation: Pediatr. Clin. North Am. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401126 Medline TA: Pediatr Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 1131-53 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics and Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. shahk@email.chop.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cafe-au-Lait Spots
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complications,
diagnosis*,
pathology Child Child Welfare Diagnosis, Differential Humans Hyperpigmentation / complications, diagnosis* Infant Infant, Newborn Neurofibromatosis 1 / diagnosis Nevus, Pigmented / diagnosis Risk Factors Skin / pathology* Skin Abnormalities / complications, diagnosis*, pathology Syndrome |
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