| Diagnostic accuracy of rhTSH test with neck ultrasonography in differentiated thyroid cancer follow-up. | |
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MedLine Citation:
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PMID: 20013608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum thyroglobulin levels measurement after injection of recombinant human thyrotropin (rh-TSH) represents the most important advance in the follow-up of patients with differentiated thyroid cancer, obtaining TSH elevation without L-thyroxine withdrawal, avoiding marked hypothyroidism symptoms. During a 4-yr period (2004-2008), 66 consecutive patients with DTC (59 papillary and 7 follicular carcinomas) were examined after rh-TSH Tg test and neck ultrasonography. In all patients basal Tg was <0.25 ng/ml. In twelve (18.5%) examined patients rh-TSH Tg was >0.25 ng/ml, and in seven (58.3%) of these was demonstrated persistent or recurrent disease. These data indicate that rhTSH-Tg>0.25 ng/ml should be considered diagnostic for persistent or recurrent disease and suggests further exams (neck ultrasonography, whole body scan or cytology) to localize the disease. Furthermore, neck ultrasonography has demonstrated high accuracy in detecting lymph nodal metastases and should be always combined with rh-TSH test. |
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Authors:
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A Fumarola; M D'Alessandri; P Dicorato; G Grani; A Maiuolo; M Ruggieri; A Calvanese |
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Publication Detail:
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Type: Journal Article Date: 2009-12-11 |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 118 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 554-6 Citation Subset: IM |
Copyright Information:
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Sapienza Università di Roma, Department of Experimental Medicine, Rome, Italy. angela.fumarola@uniroma1.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Humans Iodine Radioisotopes / therapeutic use Middle Aged Neck / ultrasonography* Neoplasm Recurrence, Local / blood, diagnosis*, ultrasonography Thyroglobulin / blood Thyroid Neoplasms / blood, diagnosis*, ultrasonography Thyroidectomy Thyrotropin / diagnostic use* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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