| Diagnosis and treatment of pouchitis. | |
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MedLine Citation:
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PMID: 12617884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Total proctocolectomy with ileal pouch-anal anastomosis is the surgical procedure of choice for the management of ulcerative colitis. Pouchitis, a non-specific inflammation of the ileal reservoir, is the most frequent complication that patients experience in the long-term. Diagnosis should be made on the basis of clinical, endoscopic and histological aspects. The Pouchitis Disease Activity Index (PDAI) represents an objective and reproducible scoring system for pouchitis: active pouchitis is defined as a score > or = 7 and remission as a score < 7. About 15% of patients develop a chronic disease. Treatment of pouchitis is empirical, and very few controlled studies have been carried out. Antibiotics, particularly metronidazole and ciprofloxacin, are the treatment of choice. Chronic pouchitis may benefit from a prolonged course of a combination of antibiotics. Highly concentrated probiotics are effective for both prevention of relapses and prevention of pouchitis onset. There is no convincing evidence of the efficacy of other therapeutic agents. |
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Authors:
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Paolo Gionchetti; Cristina Amadini; Fernando Rizzello; Alessandro Venturi; Gilberto Poggioli; Massimo Campieri |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical gastroenterology Volume: 17 ISSN: 1521-6918 ISO Abbreviation: Best Pract Res Clin Gastroenterol Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-03-05 Completed Date: 2003-07-01 Revised Date: 2006-04-13 |
Medline Journal Info:
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Nlm Unique ID: 101120605 Medline TA: Best Pract Res Clin Gastroenterol Country: England |
Other Details:
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Languages: eng Pagination: 75-87 Citation Subset: IM |
Affiliation:
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University of Bologna, Department of Internal Medicine and Gastroenterology, Policlinico S Orsola, Via Massarenti no 9, 40138 Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use Colitis, Ulcerative / therapy Diagnosis, Differential Endoscopy, Digestive System Humans Pouchitis / diagnosis*, etiology, pathology, therapy* Probiotics / therapeutic use Proctocolectomy, Restorative / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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