Document Detail


Diagnosis and treatment of lupus nephritis flares-an update.
MedLine Citation:
PMID:  23147758     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Relapses or flares of systemic lupus erythematosus (SLE) are frequent and observed in 27-66% of patients. SLE flares are defined as an increase in disease activity, in general, requiring alternative treatment or intensification of therapy. A renal flare is indicated by an increase in proteinuria and/or serum creatinine concentration, abnormal urine sediment or a reduction in creatinine clearance rate as a result of active disease. The morbidity associated with renal flares is derived from both the kidney damage due to lupus nephritis and treatment-related toxic effects. Current induction treatment protocols achieve remission in the majority of patients with lupus nephritis; however, few studies focus on treatment interventions for renal flares in these patients. The available data, however, suggest that remission can be induced again in a substantial percentage of patients experiencing a lupus nephritis flare. Lupus nephritis flares are independently associated with an increased risk of deterioration in renal function; prevention of renal flares might, therefore, also decrease long-term morbidity and mortality. Appropriate immunosuppressive maintenance therapy might lead to a decrease in the occurrence of renal and extrarenal flares in patients with SLE, and monitoring for the early detection and treatment of renal flares could improve their outcomes.
Authors:
Ben Sprangers; Marianne Monahan; Gerald B Appel
Related Documents :
1424128 - Measurement of cyclosporine by liquid chromatography and three immunoassays in blood fr...
24740848 - Aortic root rupture after tavr in two renal transplant patients on chronic immunosuppre...
22744218 - Impact of posttransplant portosystemic shunts on liver transplantation.
23467258 - Recurrence of anti-neutrophil cytoplasmic antibody-associated vasculitis in appropriate...
15023138 - Acute graft versus host disease following liver transplantation: the enemy within.
9925008 - Hypomagnesemia and mild rhabdomyolysis in living related donor renal transplant recipie...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Nature reviews. Nephrology     Volume:  -     ISSN:  1759-507X     ISO Abbreviation:  Nat Rev Nephrol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500081     Medline TA:  Nat Rev Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Kidney transplantation and the ageing immune system.
Next Document:  A new technique of endoprosthetic replacement for osteosarcoma of proximal femur with intra-articula...