Document Detail


Diagnosis and treatment for graft-versus-host disease after liver transplantation: two case reports.
MedLine Citation:
PMID:  17580224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The diagnosis and treatments were of 2 cases of graft-versus-host disease (GVHD) after liver transplantation are presented herein. METHODS: The 2 cases were diagnosed at 24 and 32 days after liver transplantation, respectively. Fever, diarrhea, skin rash, and leukopenia were symptoms in both of them. They were treated with methylprednisolone (0.5 g/d, for 3 days), G-CSF, and GM-CSF. The dose of CsA was decreased in 1 of them. RESULTS: One patient died of cerebral hemorrhage at 31 days after transplantation. The other 1 responded well to the methylprednisolone and the skin rash disappeared within 1 week after the treatment. He was discharged 50 days after transplantation. CONCLUSION: Clinicians should be familiar with the risk factors, signs, and symptoms associated with GVHD after liver transplantation. Corticosteroids are the choice of treatment for GVHD after liver transplantation. Immunosuppressive agents should be decreased when GVHD is diagnosed.
Authors:
B Wang; Y Lu; L Yu; C Liu; Z Wu; X Liu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  39     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-20     Completed Date:  2007-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1696-8     Citation Subset:  IM    
Affiliation:
Department of Hepatobiliary Surgery, First Hospital of Xian Jiaotong University, 1 Jiankang Road, Xi'an, Shaanxi Province 710061, China. smilebird75@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Graft vs Host Disease / diagnosis,  drug therapy*
Humans
Immunosuppressive Agents / adverse effects*
Liver Transplantation / adverse effects,  immunology*
Male
Methylprednisolone / therapeutic use
Middle Aged
Treatment Outcome
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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