Document Detail

Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis.
MedLine Citation:
PMID:  16597667     Owner:  NLM     Status:  MEDLINE    
AIM: To describe the diagnostic and therapeutic management of cytomegalovirus (CMV) anterior uveitis unassociated with retinal necrosis in immunocompetent patients.
METHODS: Patients referred between 2001 and 2003 for management of unilateral, chronic, recurrent uveitis associated with secondary glaucoma underwent extensive investigation including laboratory tests for herpes virus infections. Specific antiviral treatment was initiated in all cases and the level of ocular inflammation was evaluated during the follow up.
RESULTS: Five patients, three men and two women, were included. Median age was 50 years old (range 30-80 years). Anterior unilateral uveitis without iris atrophy was observed in all cases. Uveitis was chronic in three cases and recurrent in two cases. Glaucoma was observed in all patients with a median intraocular pressure of 30 mm Hg (range 22-43 mm Hg). Five patients responded initially to specific anti-CMV therapy. Even though glaucoma surgery was necessary in two cases, both ocular inflammation and glaucoma were controlled in all cases. Relapses occurred in three cases after cessation of therapy, requiring prolonged maintenance therapy with valganciclovir.
CONCLUSIONS: CMV infection and specific antiviral therapy should be considered in all cases of relapsing or chronic iridocyclitis and secondary glaucoma. Maintenance regimens of valganciclovir may be necessary to prevent further relapses.
I de Schryver; F Rozenberg; N Cassoux; S Michelson; P Kestelyn; P Lehoang; J L Davis; B Bodaghi
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Publication Detail:
Type:  Journal Article     Date:  2006-04-05
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  90     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-07-20     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  852-5     Citation Subset:  IM    
Department of Ophthalmology, University of Paris VI, Pitié-Salpêtrière Hospital, 47-83 bd de l'Hôpital, 75651 Paris, France.
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MeSH Terms
Aged, 80 and over
Antiviral Agents / therapeutic use
Chronic Disease
Cytomegalovirus* / genetics
Cytomegalovirus Infections / diagnosis*,  drug therapy
DNA, Viral / analysis
Eye Infections, Viral / diagnosis*,  drug therapy
Follow-Up Studies
Foscarnet / therapeutic use
Ganciclovir / analogs & derivatives,  therapeutic use
Glaucoma, Open-Angle / virology
Iridocyclitis / drug therapy,  virology*
Middle Aged
Retrospective Studies
Uveitis, Anterior / drug therapy,  virology
Vitreous Body / virology
Reg. No./Substance:
0/Antiviral Agents; 0/DNA, Viral; 0/valganciclovir; 4428-95-9/Foscarnet; 82410-32-0/Ganciclovir
Comment In:
Br J Ophthalmol. 2006 Jul;90(7):812-3   [PMID:  16782945 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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