Document Detail

Diagnosis-to-Treatment Interval and Control of Locoregionally Advanced Head and Neck Cancer.
MedLine Citation:
PMID:  21422314     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To assess the impact of prolonged diagnosis-to-treatment interval (DTI) that falls in the time frame associated with the increasing complexity of planning treatment for patients with locoregionally advanced head and neck cancer (LAHNC).
DESIGN: Retrospective study.
SETTING: The University of Alabama at Birmingham.
PATIENTS: An institutional database was searched for all patients with LAHNC who were treated with radiotherapy between 1995 and 2007 at the University of Alabama at Birmingham. After patients with prior treatment for head and neck cancer (including surgery or neoadjuvant chemotherapy), patients younger than 18 years, and patients with stage I or II tumors were excluded, 427 patients remained for analysis.
MAIN OUTCOME MEASURES: The DTI was defined as the time in days between the date that a biopsy specimen showing malignancy was obtained and the first day of radiotherapy.
RESULTS: The median DTI was 34 days (range, 7-441 days). A longer DTI was not significantly associated with locoregional control (P = .11), distant metastases-free survival (P = .32), or overall survival (P = .07).
CONCLUSION: A prolonged DTI did not appear to adversely affect outcomes in this cohort of patients with LAHNC.
Jimmy J Caudell; Julie L Locher; James A Bonner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  137     ISSN:  1538-361X     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-5     Citation Subset:  AIM; IM    
Department of Radiation Oncology, University of Mississippi Medical Center, 350 Woodrow Wilson Dr, Ste 1600, Jackson, MS 39213.
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