| Diagnosis and therapeutic problems of primary sclerosing cholangitis. | |
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MedLine Citation:
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PMID: 12891925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary sclerosing cholangitis (PSC) leads to a progressive destruction of the intra- and extrahepatic bile ducts. The cause is unknown but genetic and immunological mechanisms may play a role. The median survival time from diagnosis to death is about 12 years. MRCP is almost equal to ERCP for diagnosing PSC and shows the typical localised or multifocal strictures and interfering segments of ectatic bile ducts. Liver histology can be helpful in making the diagnosis but is often unspecific and there is a large sampling variability. The treatment of PSC is disappointing. The combination of ursodeoxycholic acid with endoscopic dilatation is probably the best treatment. Patients with cirrhosis and/or recurrent cholangitis should be evaluated for liver transplantation as the outcome after liver transplantation is good, especially if there is no cholangio-carcinoma present and if the Child-Pugh score is not too high. There is also a need to treat the complication of PSC such as osteoporosis, cholangitis and the development of cholangiocarcinoma. |
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Authors:
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Isabelle Colle; Hans Van Vlierberghe |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta gastro-enterologica Belgica Volume: 66 ISSN: 0001-5644 ISO Abbreviation: Acta Gastroenterol. Belg. Publication Date: 2003 Apr-Jun |
Date Detail:
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Created Date: 2003-08-01 Completed Date: 2003-09-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0414075 Medline TA: Acta Gastroenterol Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 155-9 Citation Subset: IM |
Affiliation:
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Department of Hepato-Gastroenterology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium. isabelle.colle@ugent.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholangitis, Sclerosing
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complications,
diagnosis*,
therapy* Humans Liver Diseases / etiology* Liver Transplantation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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