Document Detail

Diagnosis and therapeutic aspects of stroke.
MedLine Citation:
PMID:  8538824     Owner:  NLM     Status:  MEDLINE    
Detailed assessment of stroke is essential to distinguish haemorrhage from infarction, to establish the vascular territory affected and to identify patients with carotid stenosis or cardio-embolic disease. Computed tomography scanning should be routinely undertaken. Duplex Doppler sonography and echocardiography should be readily available but used selectively. Hypertension should not be treated early after ischaemic stroke. Issues requiring research include the optimal time to institute treatment, the degree to which blood pressure should be lowered in the presence of carotid stenosis and the value of antihypertensive treatment in normotensive survivors of stroke. Anticoagulation should be more widely applied in the prevention of stroke in patients with atrial fibrillation. Thrombolysis for acute ischaemic stroke has potential benefits and risks. It should be used only within randomised clinical trials, some of which may soon report. Endogenous glutamate causes excitotoxic damage after cerebral ischaemia. Many pharmacological approaches to restrict neuronal loss within the ischaemic penumbra are now in clinical trials. Physicians managing hypertension should take a lead in researching blood pressure management and neuroprotective strategies after acute stroke, and in directing other preventive measures such as anticoagulation for atrial fibrillation.
K R Lees; A G Dyker; A G Dykes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  47     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-02-06     Completed Date:  1996-02-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
University Department of Medicine and Therapeutics, Gardiner Institute Western Infirmary, Glasgow, UK.
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MeSH Terms
Cerebrovascular Disorders / diagnosis*,  therapy
Hypertension / complications
Erratum In:
Neth J Med 1996 Mar;48(3):123
Note: Dykes AG [corrected to Dyker AG]

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