Document Detail

Diagnosis and surgical management of locally recurrent soft-tissue sarcomas of the extremity.
MedLine Citation:
PMID:  8211194     Owner:  NLM     Status:  MEDLINE    
The patient who presents with evidence of a recurrent soft-tissue sarcoma of the extremity should have a complete history and physical examination. A diagnostic biopsy, either fine-needle or open biopsy, should be performed to confirm recurrence. Liver-function tests, complete blood cell count, electrolytes, and chest X-ray should be performed. If preliminary evaluation confirms local recurrence and is negative for regional or distant disease, a CT scan of the chest to better exclude metastases, as well as a CT or MRI of the local recurrence, should be performed. If neurovascular structures appear at risk on noninvasive scanning, an arteriogram is performed to exclude major vascular involvement. In selected circumstances, arterial and/or venous reconstruction may be indicated to allow complete gross removal of tumor. Complete removal of tumor should be combined with radiotherapy for all sarcomas with close margins and for any high-grade lesion regardless of margin status. Brachytherapy can often be used even when the patient has had prior teletherapy to the site. Complete tumor removal combined with adjuvant radiotherapy is the best way to prevent subsequent local recurrence and provide long-term survival.
E R Sauter; J P Hoffman; B L Eisenberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in oncology     Volume:  20     ISSN:  0093-7754     ISO Abbreviation:  Semin. Oncol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-15     Completed Date:  1993-11-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0420432     Medline TA:  Semin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  451-5     Citation Subset:  IM    
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.
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MeSH Terms
Combined Modality Therapy
Extremities / surgery*
Magnetic Resonance Imaging
Neoplasm Recurrence, Local / diagnosis*,  radiotherapy,  surgery*
Salvage Therapy
Sarcoma / diagnosis*,  radiotherapy,  surgery*
Survival Rate
Tomography, X-Ray Computed
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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