Document Detail

Diagnosis of subclinical rickets.
MedLine Citation:
PMID:  7377839     Owner:  NLM     Status:  MEDLINE    
44 randomly selected infants under age one year with suspected lower respiratory infections were investigated for the presence of subclinical rickets. Seven infants had metaphyseal changes at the wrist compatible with a diagnosis of rickets and all of these infants had 25-hydroxy-vitamin D (25-OHD) concentrations less than 12 ng/ml. Serum calcium and phosphorus concentrations were normal in all 44 children. Alkaline phosphatase concentrations did not correlate with the presence of metaphyseal changes. The clinical presence of craniotabes or splaying and loss of definition of the anterior ends of the ribs on x-rays did not correlate with metaphyseal changes at the wrist or with 25-OHD concentrations. An x-ray of the wrist is essential to confirm the presence of subclinical rickets and the at-risk infant can be detected by measuring serum 25-OHD concentrations.
J M Pettifor; J M Isdale; J Sahakian; J D Hansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  55     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  AIM; IM    
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MeSH Terms
Hydroxycholecalciferols / blood
Ribs / radiography
Rickets / blood,  diagnosis*,  radiography
Ulna / radiography
Reg. No./Substance:

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