Document Detail

Diagnosis, prevention, and treatment of adverse reactions to aspirin and nonsteroidal anti-inflammatory drugs.
MedLine Citation:
PMID:  6436354     Owner:  NLM     Status:  MEDLINE    
Aspirin (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs) share common pharmacologic effects in the prevention of inflammation, at least in part through inhibition of prostaglandin formation. ASA and NSAIDs have predictable side effects such as gastric pain, ecchymosis, and tinnitus. They also cause anaphylactoid shock, urticaria/angioedema, nephropathy, and hepatitis in individuals who appear to be normal and in whom prediction of such reactions cannot be made. Two selected populations of patients are likely to experience hypersensitivity reactions to both ASA and NSAIDs. Patients with asthma have an 8% to 20% chance of experiencing asthmatic attacks after ingesting ASA and NSAID. If such patients have associated rhinosinusitis (polyps), prevalence increases to 30% to 40%. Patients with chronic urticaria/angioedema have a 21% to 30% chance of experiencing an urticarial flare after ingesting ASA and NSAIDs.
D D Stevenson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  74     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-29     Completed Date:  1984-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  AIM; IM    
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MeSH Terms
Angioedema / immunology
Anti-Inflammatory Agents / adverse effects*
Aspirin / adverse effects*
Asthma / chemically induced,  immunology*
Cross Reactions
Cyclooxygenase Inhibitors
Drug Hypersensitivity / immunology,  prevention & control*
Rhinitis, Allergic, Perennial / immunology
Urticaria / immunology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cyclooxygenase Inhibitors; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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