| Diagnosis of pediatric multiple sclerosis initially presenting with tumefactive demyelinating lesion using (1)H-magnetic resonance spectroscopy. | |
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MedLine Citation:
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PMID: 21946426 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report a case of tumefactive demyelinating lesion (TDL) diagnosed using (1)H-magnetic resonance spectroscopy ((1)H-MRS) and conventional magnetic resonance imaging (MRI). A 7-year-old girl was admitted to our hospital with complaints of sleepiness and clumsiness of the right limbs. Neurological examination showed somnolence, right-sided apraxia, and hemiparesis with enhanced tendon reflexes and Babinski sign. Conventional brain MRI revealed extensive hyperintensity in the subcortical white matter of the left frontal lobe in both T(2) weighted and fluid attenuated inversion recovery images. Gadolinium-enhanced T(1) weighted images showed a tumor-like lesion in this area with interrupted rim enhancement, termed open ring sign, and a periventricular lesion along the inferior horn of the right lateral ventricle and a juxtacortical lesion under the right motor cortex. In (1)H-MRS, both single voxel spectroscopy (SVS) and chemical shift imaging showed elevation of choline and reduction of N-acetylaspartate in the left frontal lobe lesion. Furthermore, SVS with a short echo time revealed elevated peaks for glutamate/glutamine complex in this lesion. These results suggested the demyelinating nature of this tumor-like lesion, in accordance with the concept of TDL. Based on this diagnosis, we treated the patient with three sets of methylprednisolone pulse therapy, which resulted in the reduction of TDL and neurological improvement. A follow-up study using MRI also demonstrated two more lesions in the corona radiata and internal capsule of the left hemisphere, supporting a diagnosis of multiple sclerosis based on the revised McDonald's criteria (2010). We concluded that (1)H-MRS may be beneficial in the differential diagnosis of TDL. |
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Authors:
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Takashi Kageyama; Yoko Gotoh; Fumie Sano; Takeo Katoh; Mituhiko Nambu; Tsutomu Okada; Toshihiko Suenaga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rinshō shinkeigaku = Clinical neurology Volume: 51 ISSN: 0009-918X ISO Abbreviation: Rinsho Shinkeigaku Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417466 Medline TA: Rinsho Shinkeigaku Country: Japan |
Other Details:
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Languages: eng Pagination: 688-93 Citation Subset: IM |
Affiliation:
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Department of Neurology, Tenri Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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