Document Detail


Diagnosis of mantle cell lymphoma on tissue acquired by fine needle aspiration in conjunction with immunocytochemistry and cytokinetic studies. Possibilities and limitations.
MedLine Citation:
PMID:  7571969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the cytokinetic features of mantle cell lymphoma (MCL) and determine if there are measurable differences between mantle zone (MCL-MZ) and diffuse (MCL-D) types of MCL. STUDY DESIGN: Forty-five fine needle aspirates (FNAs) from 36 patients with MCL were reviewed. Immunohistochemistry, using a panel of kappa, lambda, CD5 and CD3, was applied in all cases. Ki-67 positivity using digital image analysis was measured in 29 cases. Flow cytometric analysis was performed on 40 specimens with DNA and RNA indices, and S + G2M phase was assessed. RESULTS: The great majority of cases (42 cases, 94%) were positive for CD5. There was a predominance of lambda-positive cases (lambda:kappa 2:1). MCL-D had higher mean Ki-67 values as compared to MCL-MZ (14.4% vs. 6.5%), but the differences were not statistically significant (P = .07). The majority of cases were diploid (35, 87%). MCL-D had significantly higher mean values for RNA index (P = .005). There was no significant difference in percentage of S + G2M between MCL-MZ and MCL-D; however, the diffuse type had higher mean values as compared to the mantle zone type (5.4 vs. 3.7). CONCLUSION: Tissue obtained by FNA is adequate for a diagnosis of MCL. However, while certain proliferation and RNA markers did show a trend toward being lower in MCL-MZ, differentiation between MCL-MZ and MCL-D cannot be made based on these alone; histologic architecture is necessary.
Authors:
E M Wojcik; R L Katz; T V Fanning; A el-Naggar; N G Ordonez; D Johnston
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  39     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1995-10-31     Completed Date:  1995-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  909-15     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Monoclonal
Antigens, CD5 / metabolism
Biopsy, Needle
Cell Division
Female
Flow Cytometry
Humans
Immunochemistry
Ki-67 Antigen
Lymphoma, Non-Hodgkin / diagnosis*,  pathology
Male
Middle Aged
Neoplasm Proteins / metabolism
Neoplasm Staging
Nuclear Proteins / metabolism
Proliferating Cell Nuclear Antigen / metabolism
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD5; 0/Ki-67 Antigen; 0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proliferating Cell Nuclear Antigen

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