| Diagnosis and management of pulmonary hypertension over the past 100 years. | |
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MedLine Citation:
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PMID: 17222544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary hypertension is a rare disease with a poor prognosis. It was first described in the late 19th century as a clinical-pathological syndrome characterised by obstruction of the small pulmonary arteries and right ventricular hypertrophy in patients presenting with severe dyspnoea and cyanosis. After the development of right heart catheterisation in the second half of the 20th century, it was found that many diseases could cause pulmonary hypertension, which is now recognised to be high blood pressure in the arteries that supply the lungs. In the 1960s, an epidemic of pulmonary hypertension caused by appetite suppressants initiated a systematic collection of information on pulmonary hypertension, leading to the first international classification of pulmonary hypertension. Increased understanding of the pathogenesis of the various forms of pulmonary hypertension has led to novel treatments and holds promise for the future. |
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Authors:
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S A van Wolferen; K Grünberg; A Vonk Noordegraaf |
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Publication Detail:
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Type: Historical Article; Journal Article; Review Date: 2007-01-11 |
Journal Detail:
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Title: Respiratory medicine Volume: 101 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-09 Completed Date: 2007-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 389-98 Citation Subset: IM |
Affiliation:
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Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR-VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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complications Appetite Depressants / adverse effects Disease Outbreaks Heart Diseases / complications History, 19th Century History, 20th Century Humans Hypertension, Pulmonary / diagnosis, history*, therapy Lung / blood supply, pathology, physiopathology Pulmonary Embolism / complications |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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