Document Detail

Diagnosis and management of pulmonary hypertension over the past 100 years.
MedLine Citation:
PMID:  17222544     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is a rare disease with a poor prognosis. It was first described in the late 19th century as a clinical-pathological syndrome characterised by obstruction of the small pulmonary arteries and right ventricular hypertrophy in patients presenting with severe dyspnoea and cyanosis. After the development of right heart catheterisation in the second half of the 20th century, it was found that many diseases could cause pulmonary hypertension, which is now recognised to be high blood pressure in the arteries that supply the lungs. In the 1960s, an epidemic of pulmonary hypertension caused by appetite suppressants initiated a systematic collection of information on pulmonary hypertension, leading to the first international classification of pulmonary hypertension. Increased understanding of the pathogenesis of the various forms of pulmonary hypertension has led to novel treatments and holds promise for the future.
S A van Wolferen; K Grünberg; A Vonk Noordegraaf
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Publication Detail:
Type:  Historical Article; Journal Article; Review     Date:  2007-01-11
Journal Detail:
Title:  Respiratory medicine     Volume:  101     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-09     Completed Date:  2007-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  389-98     Citation Subset:  IM    
Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR-VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
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MeSH Terms
Anoxia / complications
Appetite Depressants / adverse effects
Disease Outbreaks
Heart Diseases / complications
History, 19th Century
History, 20th Century
Hypertension, Pulmonary / diagnosis,  history*,  therapy
Lung / blood supply,  pathology,  physiopathology
Pulmonary Embolism / complications
Reg. No./Substance:
0/Appetite Depressants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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