| Diagnosis and management of primary aldosteronism. | |
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MedLine Citation:
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PMID: 18594273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To illustrate the steps for clinical management of primary aldosteronism from screening evaluation to surgical and/or medical treatment. RECENT FINDINGS: It is now widely accepted that primary aldosteronism represents the most common form of endocrine hypertension and its early diagnosis is crucial for hypertensive patients who can be cured by the surgical removal of an aldosterone-secreting adenoma or benefit from a specific medical treatment with mineralocorticoid receptor antagonists. Recent evidence indicates that hyperaldosteronism is indeed associated with detrimental consequences on cardiovascular system, renal function and glucose metabolism. SUMMARY: The diagnostic protocol for primary aldosteronism requires multistep evaluation and should begin with a screening test, followed when appropriate, by confirmatory test and functional and anatomical evaluation. Finally, although it is technically difficult and the cut-off levels for acceptance of the success are not standardized, the subtype forms should be identified using a selective adrenal venous sampling. |
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Authors:
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Marco Boscaro; Vanessa Ronconi; Federica Turchi; Gilberta Giacchetti |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in endocrinology, diabetes, and obesity Volume: 15 ISSN: 1752-2978 ISO Abbreviation: - Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
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Languages: eng Pagination: 332-8 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Universitá Politecnica delle Marche, Ancona, Italy. m.boscaro@univpm.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Neoplasms
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diagnosis,
surgery Adrenal Glands / surgery Adrenocortical Adenoma / metabolism Aldosterone Antagonists / therapeutic use Diagnosis, Differential Humans Hyperaldosteronism / diagnosis*, drug therapy Hypertension / diagnosis Hypokalemia / diagnosis Receptors, Mineralocorticoid / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Receptors, Mineralocorticoid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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