Document Detail

Diagnosis and management of large toxic multinodular goiters.
MedLine Citation:
PMID:  2411889     Owner:  NLM     Status:  MEDLINE    
Toxic multinodular goiters, estimated weight 100 g or more, occurred in 35 patients between 1961 and 1984. All but two were older than 50; 32 were females. Twenty had goiters of 100-130 g; four of 140-200 g; and 11 were massive. Radioiodine uptakes were 30% or less for 22. Seven of 17 with both T4 and T3 data had T4 toxicosis. Thirty-two patients received radioiodine therapy, delivering 200 microCi per gram when possible. Doses were 25-30 mCi for 17 patients; 50-100 mCi for 12 patients, and 150-200 mCi for three patients. Hyperthyroidism was eliminated with one dose in 25 patients (78%); five patients required two doses. Twenty-two patients were euthyroid after radioiodine; 25 of 28 had persistent goiters. Two patients were treated successfully surgically. One refused surgery and radioiodine, and has been maintained on antithyroid drugs for 10 yr. Two patients died within a few months of an unsuccessful initial dose of radioiodine. Large dose radioiodine therapy is simple, safe, and effective for most patients with large toxic multinodular goiters.
J I Hamburger; S W Hamburger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  26     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  888-92     Citation Subset:  IM    
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MeSH Terms
Antithyroid Agents / therapeutic use
Diagnosis, Differential
Goiter, Nodular / complications,  diagnosis*,  radiotherapy,  therapy
Graves Disease / diagnosis
Heart Diseases / etiology,  therapy
Hyperthyroidism / etiology,  therapy
Iodine Radioisotopes / diagnostic use,  therapeutic use
Middle Aged
Thyroid Hormones / blood
Reg. No./Substance:
0/Antithyroid Agents; 0/Iodine Radioisotopes; 0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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