| Diagnosis and management of large toxic multinodular goiters. | |
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MedLine Citation:
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PMID: 2411889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toxic multinodular goiters, estimated weight 100 g or more, occurred in 35 patients between 1961 and 1984. All but two were older than 50; 32 were females. Twenty had goiters of 100-130 g; four of 140-200 g; and 11 were massive. Radioiodine uptakes were 30% or less for 22. Seven of 17 with both T4 and T3 data had T4 toxicosis. Thirty-two patients received radioiodine therapy, delivering 200 microCi per gram when possible. Doses were 25-30 mCi for 17 patients; 50-100 mCi for 12 patients, and 150-200 mCi for three patients. Hyperthyroidism was eliminated with one dose in 25 patients (78%); five patients required two doses. Twenty-two patients were euthyroid after radioiodine; 25 of 28 had persistent goiters. Two patients were treated successfully surgically. One refused surgery and radioiodine, and has been maintained on antithyroid drugs for 10 yr. Two patients died within a few months of an unsuccessful initial dose of radioiodine. Large dose radioiodine therapy is simple, safe, and effective for most patients with large toxic multinodular goiters. |
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Authors:
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J I Hamburger; S W Hamburger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 26 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-10-10 Completed Date: 1985-10-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 888-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antithyroid Agents / therapeutic use Diagnosis, Differential Female Goiter, Nodular / complications, diagnosis*, radiotherapy, therapy Graves Disease / diagnosis Heart Diseases / etiology, therapy Humans Hyperthyroidism / etiology, therapy Iodine Radioisotopes / diagnostic use, therapeutic use Male Middle Aged Thyroid Hormones / blood Thyroidectomy |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 0/Iodine Radioisotopes; 0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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