Document Detail

Diagnosis & management of leishmania/HIV co-infection.
MedLine Citation:
PMID:  15817953     Owner:  NLM     Status:  MEDLINE    
Leishmaniasis, a globally prevalent parasitic disease occurs in three forms viz., visceral, cutaneous and mucocutaneous, transmitted by the bite of infected female Phlebotomus sandflies. Visceral leishmaniasis (VL) has 100 per cent fatality rate, if left untreated. India has the largest burden of this disease. HIV infection is also increasing worldwide and several reports indicate rising trend of VL/ HIV co-infection, modifying the traditional anthroponotic pattern of VL transmission. Both VL and HIV tend to lower the cell mediated immunity (CMI) resulting in poor drug response and opportunistic infections involving gastrointestinal, cutaneous, respiratory tract and central nervous system (CNS) may occur. Diagnosis of such co-infected cases is quite difficult. However, newer tests like nested PCR, rk39 immunochromatographic test etc., can be of help. Response to different antileishmanial drugs like sodium antimony gluconate (SAG), amphotericin B is far from satisfactory. However, a new oral drug miltefosine has been found to be promising. Highly active antiretroviral therapy (HAART) need to be given for management of HIV infection along with treatment of other opportunistic infections.
P K Sinha; K Pandey; S K Bhattacharya
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  121     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-08     Completed Date:  2005-07-05     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  407-14     Citation Subset:  IM    
Rajendra Memorial Research Institute of Medical Sciences (ICMR), Agamkuan, Patna 800 007, India.
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MeSH Terms
HIV Infections / complications*
Leishmaniasis / classification,  complications,  diagnosis*,  drug therapy

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