| Diagnosis of liver metastases from colorectal adenocarcinoma. Comparison of spiral-CTAP combined with intravenous contrast-enhanced spiral-CT and SPIO-enhanced MR combined with plain MR imaging. | |
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MedLine Citation:
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PMID: 9394654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to determine whether MR with and without SPIO (AMI-25) could replace spiral-CTAP in the staging of colorectal adenocarcinoma. MATERIAL AND METHODS: Thirty-five patients were studied prospectively by means of i.v. contrast-enhanced spiral-CT, spiral-CTAP, and MR of the liver. MR imaging was performed before and after infusion of AMI-25. Diagnoses were compared to intraoperative findings (n = 35) which included intraoperative ultrasound (n = 21), and follow-up CT (n = 18). RESULTS AND CONCLUSION: Fifteen patients were found to have a total number of 53 liver metastases and 43 benign lesions were detected. Evaluation was performed in four different ways: 1) i.v. contrast-enhanced spiral-CT; 2) i.v. contrast-enhanced spiral-CT + spiral-CTAP; 3) plain MR; 4) plain MR + SPIO-enhanced MR. I.v. contrast-enhanced spiral-CT, spiral-CTAP and SPIO-enhanced MR identified patients with liver metastases with equal sensitivity. However, owing to its significantly higher sensitivity, based on a lesion-by-lesion analysis, spiral-CTAP cannot be replaced by SPIO-enhanced MR in patients who are to undergo liver resection. A limitation in spiral-CTAP is its relatively low specificity. |
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Authors:
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M Strotzer; J Gmeinwieser; J Schmidt; C Fellner; J Seitz; H Albrich; H Zirngibl; S Feuerbach |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 38 ISSN: 0284-1851 ISO Abbreviation: Acta Radiol Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1997-12-30 Completed Date: 1997-12-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 986-92 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University Hospital, Regensburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
/
diagnosis,
pathology,
radiography,
secondary* Adult Aged Aged, 80 and over Colonic Neoplasms / pathology* Contrast Media* Female Ferrosoferric Oxide Follow-Up Studies Hepatectomy Humans Image Enhancement / methods Infusions, Intravenous Intraoperative Care Iron / diagnostic use* Liver Neoplasms / diagnosis, radiography, secondary* Magnetic Resonance Imaging / methods* Male Middle Aged Oxides / diagnostic use* Portography / methods* Prospective Studies Radiographic Image Enhancement / methods Rectal Neoplasms / pathology* Sensitivity and Specificity Single-Blind Method Suspensions Tomography, X-Ray Computed / methods* Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Oxides; 0/Suspensions; 119683-68-0/ferumoxides; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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