| Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria? | |
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MedLine Citation:
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PMID: 17993472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Left-ventricular non-compaction (LVNC) is characterized by excessive and prominent left-ventricular (LV) trabeculations and may be associated with systolic dysfunction in advanced disease. We sought to determine the proportion of patients fulfilling LVNC criteria in an adult population referred to a heart failure clinic using current diagnostic criteria. METHODS AND RESULTS: One hundred and ninety-nine patients [age 63.5 +/- 15.9 years, 124 (62.3%) males] with LV systolic impairment were studied. All underwent clinical examination, electrocardiography, and 2-D echocardiography. The number of patients fulfilling diagnostic criteria for LVNC was retrospectively determined using three published definitions. Results were compared with 60 prospectively evaluated normal controls (age 35.7 +/- 13.5 years; 31 males, 30 blacks). Forty-seven patients (23.6%) fulfilled one or more echocardiographic definitions for LVNC. Patients fulfilling LVNC criteria were younger (P = 0.002), had larger LV end-diastolic dimension (P < 0.001), and smaller left atrial size (P = 0.01). LVNC was more common in black individuals (35.5 vs. 16.2%, P = 0.003). Five controls (four blacks) fulfilled one or more LVNC criteria. CONCLUSIONS: This study demonstrates an unexpectedly high percentage of patients with heart failure fulfilling current echocardiographic criteria for LVNC. This might be explained by a hitherto underestimated cause of heart failure, but the comparison with controls suggests that current diagnostic criteria are too sensitive, particularly in black individuals. |
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Authors:
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Sanjay K Kohli; Antonios A Pantazis; Jaymin S Shah; Benjamin Adeyemi; Gordon Jackson; William J McKenna; Sanjay Sharma; Perry M Elliott |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-09 |
Journal Detail:
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Title: European heart journal Volume: 29 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-02 Completed Date: 2008-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 89-95 Citation Subset: IM |
Affiliation:
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The Heart Hospital, University College, 16-18 Westmoreland Street, W1G 8PH London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Echocardiography, Transesophageal / standards Electrocardiography / standards Female Heart Failure / diagnosis* Humans Male Middle Aged Sensitivity and Specificity Ventricular Dysfunction, Left / diagnosis* |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2008 Jan;29(1):10-1
[PMID:
18045855
]
Eur Heart J. 2008 Apr;29(7):951; author reply 951-2 [PMID: 18270215 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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