Document Detail

Diagnosis of intraocular lymphoma.
MedLine Citation:
PMID:  15209459     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To review current techniques for the diagnosis of intraocular lymphoma. METHODS: Literature review. RESULTS: There are a limited number of small case series and case reports reporting the diagnosis of intraocular lymphoma. Limitations in the ability to diagnose lymphoma through cytologic examination of the vitreous has led to investigations into immunohistochemistry either manually or by automated cytofluorography, intraocular cytokine determinations, and polymerase chain reaction of the vitreous or tissue lymphoid cells to detect gene rearrangements in the IgH, bcl-2, or T-cell receptor gamma gene. Data regarding diagnostic efficiency of the various testing strategies is limited by small patient numbers. Careful handling of the vitreous specimen and adequate laboratory and pathological support is critical. CONCLUSIONS: Despite a proliferation of new techniques for the diagnosis of intraocular lymphoma, none is clearly superior. Use of multiple testing strategies may improve diagnostic yield.
Janet L Davis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  12     ISSN:  0927-3948     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-06-22     Completed Date:  2004-07-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  7-16     Citation Subset:  IM    
University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, FL 33136, USA.
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MeSH Terms
Diagnostic Techniques, Ophthalmological*
Eye Neoplasms / diagnosis*
Lymphoma / diagnosis*
Polymerase Chain Reaction
Retinal Neoplasms / diagnosis*
Vitreous Body / pathology*

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