Document Detail


Diagnosis and inflammatory response of patients with candiduria.
MedLine Citation:
PMID:  22574854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Candiduria is common in hospitalised patients, but the clinical relevance is still unclear. This study was done to further our knowledge on detection of and host responses to candiduria. Urines and clinical data from 136 patients in whom presence of yeast was diagnosed by microscopic urinalysis were collected. Diagnosis by standard urine culture methods on blood and MacConkey agar as well as on fungal culture medium (Sabouraud dextrose agar) was compared. Inflammatory parameters (IL-6 and IL-17, Ig) were quantified in the urine and compared with levels in control patients without candiduria. Standard urine culture methods detected only 37% of Candida spp. in urine. Sensitivity was especially low (23%) for C. glabrata and was independent of fungal burden. Candida specific IgG but not IgA was significantly elevated when compared with control patients (P < 0.0001 and 0.07 respectively). In addition, urine levels of IL-6 and IL-17 were significantly higher in candiduric patients when compared with control patients (P < 0.001). Multivariate analysis documented an independent association between an increased IgG (odds ratio (OR) 136.0, 95% confidence interval (CI) 25.7-719.2; P < 0.0001), an increased IL-17 (OR 17.4, 95% CI 5.3-57.0; P < 0.0001) and an increased IL-6 level (OR 4.9, 95% CI 1.9-12.4; P = 0.001) and candiduria. In summary, our data indicate that clinical studies on candiduria should include fungal urine culture and that inflammatory parameters may be helpful to identify patients with clinically relevant candiduria.
Authors:
S Helbig; J M Achkar; N Jain; X Wang; P Gialanella; M Levi; B C Fries
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-10
Journal Detail:
Title:  Mycoses     Volume:  56     ISSN:  1439-0507     ISO Abbreviation:  Mycoses     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-07-30     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  61-9     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Verlag GmbH.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Candidiasis / diagnosis*,  immunology
Child
Child, Preschool
Cytokines / urine
Female
Humans
Immunoglobulins / urine
Inflammation / etiology*
Male
Middle Aged
Urinary Tract Infections / diagnosis*,  immunology
Grant Support
ID/Acronym/Agency:
2 R01 AI059681-06/AI/NIAID NIH HHS; AI-067665/AI/NIAID NIH HHS; AI-51519/AI/NIAID NIH HHS; R01 AI059681/AI/NIAID NIH HHS; R01 AI059681-07/AI/NIAID NIH HHS; R21AI087564-01/AI/NIAID NIH HHS; T32 AI 07506/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Immunoglobulins
Comments/Corrections

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