Document Detail


Diagnosis of herpes simplex encephalitis by magnetic resonance imaging and polymerase chain reaction assay of cerebrospinal fluid.
MedLine Citation:
PMID:  9619637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The early diagnosis of herpes simplex encephalitis (HSE) is essential because early introduction of antiviral therapy can significantly reduce the mortality of this disease. Herpes simplex virus (HSV) DNA detection in cerebrospinal fluid (CSF) samples is a rapid, noninvasive, specific, and highly sensitive method for HSE diagnosis. Neurodiagnostic methods have also been studied for noninvasive diagnosis of HSE. Magnetic resonance imaging (MRI) seems to be the most sensitive of them but it has not been compared to PCR in terms of efficacy for HSE diagnosis. In this study, 17 patients with focal encephalitis were prospectively evaluated by PCR analysis of CSF samples and MRI examination. MRI lesions involving the inferomedial region of one or both temporal lobes were observed in all PCR-positive patients but one. No PCR-negative patient presented with the same pattern of MRI lesions. MRI was also important for the establishment of an alternative diagnosis in three of eight PCR-negative patients. Both methods should be routinely applied in the evaluation of presumed HSE cases.
Authors:
R B Domingues; M C Fink; A M Tsanaclis; C C de Castro; G G Cerri; M S Mayo; F D Lakeman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  157     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1998 May 
Date Detail:
Created Date:  1999-01-05     Completed Date:  1999-01-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
Affiliation:
Virology Laboratory-Tropical Medicine Institute, University of São Paulo, Brazil. renan@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Encephalitis, Viral / cerebrospinal fluid*,  diagnosis*,  virology
Female
Herpes Simplex / cerebrospinal fluid*,  diagnosis*,  virology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Polymerase Chain Reaction
Prospective Studies
Simplexvirus / genetics,  isolation & purification*
Grant Support
ID/Acronym/Agency:
N01-AI-12667/AI/NIAID NIH HHS; N01-AI-15113/AI/NIAID NIH HHS; N01-AI-62554/AI/NIAID NIH HHS

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