Document Detail

Diagnosis of hereditary spherocytosis in newborn infants.
MedLine Citation:
PMID:  6886914     Owner:  NLM     Status:  MEDLINE    
The normal range of red blood cell osmotic fragility and autohemolysis was determined in venous blood of 32 healthy newborn infants. With these normal ranges as a reference, the diagnosis of hereditary spherocytosis was definitely possible in five newborn infants by demonstration of increased osmotic fragility of fresh and incubated red blood cells, moderately increased autohemolysis, and partial reduction of autohemolysis by the addition of glucose. Most previously studied newborn infants with hereditary spherocytosis have had atypical hyperbilirubinemia. Inconstant signs are anemia, reticulocytosis, erythroblastosis, spherocytes in the blood smear, and increased mean corpuscular hemoglobin concentration. In newborn infants with atypical hyperbilirubinemia in whom blood group incompatibilities are excluded, studies for hereditary spherocytosis should be done.
W Schröter; E Kahsnitz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  103     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  460-3     Citation Subset:  AIM; IM    
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MeSH Terms
Diagnosis, Differential
Erythrocytes / physiology
Glucose / diagnostic use
Infant, Newborn
Infant, Newborn, Diseases / blood*
Osmotic Fragility
Spherocytosis, Hereditary / blood*
Reg. No./Substance:

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