| Diagnosis of gout by ultrasound. | |
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MedLine Citation:
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PMID: 17468505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To establish the usefulness of ultrasonography (US) for diagnosing gout and to determine whether there are sonographic features that are characteristic for gout but not for other arthropathies. METHODS: We retrospectively compared joint images of gout patients with matching images from patients with other rheumatic conditions. Images of 37 joints of 23 patients with monosodium urate (MSU) crystal-proven gout were reviewed. MSU crystals were identified in at least one joint in each patient. Our control group had 23 randomly selected patients with 33 examined joints with rheumatic conditions other than gout. RESULTS: Specific diagnostic features included a hyperechoic, irregular band over the superficial margin of the articular cartilage described as a double contour sign in 92% of gouty joints and in none of the controls (P < 0.001); hypoechoic to hyperechoic, inhomogeneous material surrounded by a small anechoic rim, representing tophaceous material, was seen in all gouty metatarsophalangeal (MTP) joints, in all metacarpophalangeal (MCP) joints and in none of the controls (P < 0.001); erosions adjacent to tophaceous material were seen in 65% of MTP joints and in 25% of MCP joints. One erosion was seen in a MTP joint in a control patient with psoriatic arthritis. CONCLUSIONS: US can detect deposition of MSU crystals on cartilaginous surfaces (P < 0.001) as well as tophaceous material and typical erosions. US may serve as a non-invasive means to diagnose gout. |
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Authors:
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R G Thiele; N Schlesinger |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-04-27 |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 46 ISSN: 1462-0324 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 1116-21 Citation Subset: AIM; IM |
Affiliation:
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Rheumatology Division, Department of Medicine Cooper University Hospital, Camden, NJ, USA. ralf_thiele@urmc.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cartilage, Articular / ultrasonography Crystallization Female Gout / ultrasonography* Humans Joints / ultrasonography* Knee Joint / ultrasonography Male Metacarpophalangeal Joint / ultrasonography Metatarsophalangeal Joint / ultrasonography Middle Aged Rheumatic Diseases / ultrasonography Sensitivity and Specificity Synovial Fluid / chemistry Uric Acid / analysis |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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